5-(4-fluorophenyl)-6-{hydroxy[4-(trifluoromethoxy)phenyl]methyl}-7-isopropylspiro[chromen-2,1'-cyclobutan]-4(3H)-one

Base Information

Chemical Name:5-(4-fluorophenyl)-6-{hydroxy[4-(trifluoromethoxy)phenyl]methyl}-7-isopropylspiro[chromen-2,1'-cyclobutan]-4(3H)-one
CAS No.:950674-80-3
Molecular Formula:C₂₉H₂₆F₄O₄
Molecular Weight:514.517
Hs Code.:

Synonyms:5-(4-fluorophenyl)-6-{hydroxy[4-(trifluoromethoxy)phenyl]methyl}-7-isopropylspiro[chromen-2,1'-cyclobutan]-4(3H)-one

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Chemical Property of 5-(4-fluorophenyl)-6-{hydroxy[4-(trifluoromethoxy)phenyl]methyl}-7-isopropylspiro[chromen-2,1'-cyclobutan]-4(3H)-one

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Technology Process of 5-(4-fluorophenyl)-6-{hydroxy[4-(trifluoromethoxy)phenyl]methyl}-7-isopropylspiro[chromen-2,1'-cyclobutan]-4(3H)-one

There total 1 articles about 5-(4-fluorophenyl)-6-{hydroxy[4-(trifluoromethoxy)phenyl]methyl}-7-isopropylspiro[chromen-2,1'-cyclobutan]-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 950674-72-3
5-(4-fluorophenyl)-7-isopropyl-4-oxo-3,4-dihydrospiro[chromen-2,1'-cyclobutane]-6-carbaldehyde

: 169222-42-8
(4-(trifluoromethoxy)-phenyl)magnesium bromide

: 950674-80-3
5-(4-fluorophenyl)-6-{hydroxy[4-(trifluoromethoxy)phenyl]methyl}-7-isopropylspiro[chromen-2,1'-cyclobutan]-4(3H)-one

Guidance literature:: 5-(4-fluorophenyl)-7-isopropyl-4-oxo-3,4-dihydrospiro[chromen-2,1'-cyclobutane]-6-carbaldehyde; (4-(trifluoromethoxy)-phenyl)magnesium bromide; In tetrahydrofuran; at -78 - 0 ℃; Inert atmosphere;

With water; sodium hydrogencarbonate; In tetrahydrofuran;

Reference yield: 74.0%

: 950674-80-3
5-(4-fluorophenyl)-6-{hydroxy[4-(trifluoromethoxy)phenyl]methyl}-7-isopropylspiro[chromen-2,1'-cyclobutan]-4(3H)-one

: 950674-81-4
5-(4-fluorophenyl)-6-{fluoro[4-(trifluoromethoxy)phenyl]methyl}-7-isopropylspiro[chromen-2,1'-cyclobutan]-4(3H)-one

Guidance literature:: With diethylamino-sulfur trifluoride; In toluene; at -78 ℃; Inert atmosphere;

Reference yield: 33.0%

: 950674-80-3
5-(4-fluorophenyl)-6-{hydroxy[4-(trifluoromethoxy)phenyl]methyl}-7-isopropylspiro[chromen-2,1'-cyclobutan]-4(3H)-one

: (4R)-5-(4-fluorophenyl)-6-{(R)-hydroxy[4-(trifluoromethoxy)phenyl]methyl}-7-isopropyl-3,4-di-hydrospiro[chromen-2,1'-cyclobutan]-4-ol

: 950673-97-9
(4S)-5-(4-fluorophenyl)-6-{(R)-hydroxy[4-(trifluoromethoxy)phenyl]methyl}-7-isopropyl-3,4-di-hydrospiro[chromen-2,1'-cyclobutan]-4-ol

: 950673-96-8
(4S)-5-(4-fluorophenyl)-6-{(S)-hydroxy[4-(trifluoromethoxy)phenyl]methyl}-7-isopropyl-3,4-di-hydrospiro[chromen-2,1'-cyclobutan]-4-ol

Guidance literature:: 5-(4-fluorophenyl)-6-{hydroxy[4-(trifluoromethoxy)phenyl]methyl}-7-isopropylspiro[chromen-2,1'-cyclobutan]-4(3H)-one; With borane N,N-diethylaniline complex; (1R,2S)-1-Amino-2-indanol; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

With methanol; In tetrahydrofuran; for 0.25h;