5-(4-fluorophenyl)-7-isopropyl-4-oxo-3,4-dihydrospiro[chromen-2,1'-cyclobutane]-6-carbaldehyde

Base Information

Chemical Name:5-(4-fluorophenyl)-7-isopropyl-4-oxo-3,4-dihydrospiro[chromen-2,1'-cyclobutane]-6-carbaldehyde
CAS No.:950674-72-3
Molecular Formula:C₂₂H₂₁FO₃
Molecular Weight:352.405
Hs Code.:

Synonyms:5-(4-fluorophenyl)-7-isopropyl-4-oxo-3,4-dihydrospiro[chromen-2,1'-cyclobutane]-6-carbaldehyde

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Chemical Property of 5-(4-fluorophenyl)-7-isopropyl-4-oxo-3,4-dihydrospiro[chromen-2,1'-cyclobutane]-6-carbaldehyde

Chemical Property:

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Technology Process of 5-(4-fluorophenyl)-7-isopropyl-4-oxo-3,4-dihydrospiro[chromen-2,1'-cyclobutane]-6-carbaldehyde

There total 2 articles about 5-(4-fluorophenyl)-7-isopropyl-4-oxo-3,4-dihydrospiro[chromen-2,1'-cyclobutane]-6-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 950674-70-1
6-formyl-7-isopropyl-4-oxo-3,4-dihydrospiro[chromen-2,1'-cyclobutan]-5-yl trifluoromethanesulfonate

: 1765-93-1
4-fluoroboronic acid

: 950674-73-4
5-(4-fluorophenyl)-4-oxo-7-propyl-3,4-dihydrospiro[chromen-2,1'-cyclobutane]-6-carbaldehyde

: 950674-72-3
5-(4-fluorophenyl)-7-isopropyl-4-oxo-3,4-dihydrospiro[chromen-2,1'-cyclobutane]-6-carbaldehyde

Guidance literature:: With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; Reflux; Inert atmosphere;

Reference yield:

: 950674-70-1
6-formyl-7-isopropyl-4-oxo-3,4-dihydrospiro[chromen-2,1'-cyclobutan]-5-yl trifluoromethanesulfonate

: 1765-93-1
4-fluoroboronic acid

: 950674-72-3
5-(4-fluorophenyl)-7-isopropyl-4-oxo-3,4-dihydrospiro[chromen-2,1'-cyclobutane]-6-carbaldehyde

Guidance literature:: With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; at 100 ℃; for 18h;
DOI:10.1016/j.bmcl.2010.10.110

Reference yield: 64.0%

: 950674-72-3
5-(4-fluorophenyl)-7-isopropyl-4-oxo-3,4-dihydrospiro[chromen-2,1'-cyclobutane]-6-carbaldehyde

: 402-51-7
4-(trifluoromethyl)phenylmagnesium bromide

: 950674-74-5
5-(4-fluorophenyl)-6-{hydroxy[4-(trifluoromethyl)phenyl]methyl}-7-isopropylspiro[chromen-2,1'-cyclobutan]-4(3H)-one

Guidance literature:: 5-(4-fluorophenyl)-7-isopropyl-4-oxo-3,4-dihydrospiro[chromen-2,1'-cyclobutane]-6-carbaldehyde; 4-(trifluoromethyl)phenylmagnesium bromide; In tetrahydrofuran; at -78 - 0 ℃; Inert atmosphere;

With water; sodium hydrogencarbonate; In tetrahydrofuran;