(1R,2R,6S,7S)-4-(2-Benzylamino-ethyl)-4-aza-tricyclo[5.2.1.0^2,6]dec-8-ene-3,5-dione

Base Information

• Chemical Name: (1R,2R,6S,7S)-4-(2-Benzylamino-ethyl)-4-aza-tricyclo[5.2.1.0^2,6]dec-8-ene-3,5-dione
• CAS No.: 406214-96-8
• Molecular Formula: C₁₈H₂₀N₂O₂
• Molecular Weight: 296.369

Synonyms:(1R,2R,6S,7S)-4-(2-Benzylamino-ethyl)-4-aza-tricyclo[5.2.1.0^2,6]dec-8-ene-3,5-dione

Chemical Property of (1R,2R,6S,7S)-4-(2-Benzylamino-ethyl)-4-aza-tricyclo[5.2.1.0^2,6]dec-8-ene-3,5-dione

Chemical Property:

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Technology Process of (1R,2R,6S,7S)-4-(2-Benzylamino-ethyl)-4-aza-tricyclo[5.2.1.0^2,6]dec-8-ene-3,5-dione

There total 5 articles about (1R,2R,6S,7S)-4-(2-Benzylamino-ethyl)-4-aza-tricyclo[5.2.1.0^2,6]dec-8-ene-3,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

(1R,2R,6S,7S)-4-(2-{[1-Phenyl-meth-(E)-ylidene]-amino}-ethyl)-4-aza-tricyclo[5.2.1.02,6]dec-8-ene-3,5-dione (406214-99-1) → (1R,2R,6S,7S)-4-(2-Benzylamino-ethyl)-4-aza-tricyclo[5.2.1.02,6]dec-8-ene-3,5-dione (406214-96-8)

Guidance literature:

With sodium cyanoborohydride; acetic acid; In methanol; for 4h;

Reference yield:

benzaldehyde (100-52-7) → (1R,2R,6S,7S)-4-(2-Benzylamino-ethyl)-4-aza-tricyclo[5.2.1.02,6]dec-8-ene-3,5-dione (406214-96-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / Et₃N; MgSO₄ / CH₂Cl₂

2: 54 percent / NaBH₃CN; AcOH / methanol / 4 h

With sodium cyanoborohydride; magnesium sulfate; acetic acid; triethylamine; In methanol; dichloromethane;

Reference yield:

(1R,2R,6S,7S)-4-oxa-tricyclo[5.2.1.02,6]dec-8-ene-3,5-dione (2746-19-2) → (1R,2R,6S,7S)-4-(2-Benzylamino-ethyl)-4-aza-tricyclo[5.2.1.02,6]dec-8-ene-3,5-dione (406214-96-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 92 percent / toluene / 64 h / Heating

2: 86 percent / CH₂Cl₂

3: 100 percent / Et₃N; MgSO₄ / CH₂Cl₂

4: 54 percent / NaBH₃CN; AcOH / methanol / 4 h

With sodium cyanoborohydride; magnesium sulfate; acetic acid; triethylamine; In methanol; dichloromethane; toluene;

upstream raw materials:

(1R,2R,6S,7S)-4-(2-{[1-Phenyl-meth-(E)-ylidene]-amino}-ethyl)-4-aza-tricyclo[5.2.1.0^2,6]dec-8-ene-3,5-dione

benzaldehyde

(1R,2R,6S,7S)-4-oxa-tricyclo[5.2.1.0^2,6]dec-8-ene-3,5-dione

Downstream raw materials:

2-(2-acetylamino-6-oxo-1,6-dihydro-purin-7-yl)-N-benzyl-N-[2-(3,5-dioxo-4-aza-tricyclo[5.2.1.0^2,6]dec-8-en-4-yl)-ethyl]-acetamide

[9-({benzyl-[2-(3,5-dioxo-4-aza-tricyclo[5.2.1.0^2,6]dec-8-en-4-yl)-ethyl]-carbamoyl}-methyl)-9H-purin-6-yl]-carbamic acid tert-butyl ester

2-(2-acetylamino-6-oxo-1,6-dihydro-purin-9-yl)-N-benzyl-N-[2-(3,5-dioxo-4-aza-tricyclo[5.2.1.0^2,6]dec-8-en-4-yl)-ethyl]-acetamide

Diphenyl-carbamic acid 2-acetylamino-9-({benzyl-[2-((1S,2S,6R,7R)-3,5-dioxo-4-aza-tricyclo[5.2.1.0^2,6]dec-8-en-4-yl)-ethyl]-carbamoyl}-methyl)-9H-purin-6-yl ester

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