(S)-tert-butyl2-(4-fluorophenylamino)-2-oxo-1-phenylethyl-(methyl)carbamate

Base Information

Chemical Name:(S)-tert-butyl2-(4-fluorophenylamino)-2-oxo-1-phenylethyl-(methyl)carbamate
CAS No.:1361409-73-5
Molecular Formula:C₂₀H₂₃FN₂O₃
Molecular Weight:358.413
Hs Code.:

Synonyms:(S)-tert-butyl2-(4-fluorophenylamino)-2-oxo-1-phenylethyl-(methyl)carbamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-tert-butyl2-(4-fluorophenylamino)-2-oxo-1-phenylethyl-(methyl)carbamate

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Technology Process of (S)-tert-butyl2-(4-fluorophenylamino)-2-oxo-1-phenylethyl-(methyl)carbamate

There total 1 articles about (S)-tert-butyl2-(4-fluorophenylamino)-2-oxo-1-phenylethyl-(methyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 30925-08-7,30925-12-3,30925-11-2
(S)-1-(N-tert-butoxycarbonyl-N-methylamino)-1-phenylacetic acid

: 371-40-4
4-fluoroaniline

: 1361409-73-5
(S)-tert-butyl2-(4-fluorophenylamino)-2-oxo-1-phenylethyl-(methyl)carbamate

Guidance literature:: (S)-1-(N-tert-butoxycarbonyl-N-methylamino)-1-phenylacetic acid; 4-fluoroaniline; With benzotriazol-1-ol; In dichloromethane; N,N-dimethyl-formamide; at 0 ℃; for 0.166667h;

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/j.bmcl.2011.12.128

Reference yield: 99.0%

: 1361409-73-5
(S)-tert-butyl2-(4-fluorophenylamino)-2-oxo-1-phenylethyl-(methyl)carbamate

: 1374333-12-6
C₁₅H₁₅FN₂O

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.5h;
DOI:10.1016/j.bmcl.2011.12.128

Reference yield:

: 1361409-73-5
(S)-tert-butyl2-(4-fluorophenylamino)-2-oxo-1-phenylethyl-(methyl)carbamate

: 1361409-71-3
(S)-2-(2-(1H-indol-3-yl)-N-methylacetamido)-N-(4-fluorophenyl)-2-phenylacetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

2.1: dmap / dichloromethane; N,N-dimethyl-formamide / 0.17 h / 0 °C

2.2: 20 °C

With dmap; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.12.128