(2R,3S,4S,5R)-2-(6-Amino-2-phenyl-purin-9-yl)-5-hydroxymethyl-tetrahydro-furan-3,4-diol

Base Information

Chemical Name:(2R,3S,4S,5R)-2-(6-Amino-2-phenyl-purin-9-yl)-5-hydroxymethyl-tetrahydro-furan-3,4-diol
CAS No.:125339-07-3
Molecular Formula:C₁₆H₁₇N₅O₄
Molecular Weight:343.342
Hs Code.:

Synonyms:(2R,3S,4S,5R)-2-(6-Amino-2-phenyl-purin-9-yl)-5-hydroxymethyl-tetrahydro-furan-3,4-diol

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Chemical Property of (2R,3S,4S,5R)-2-(6-Amino-2-phenyl-purin-9-yl)-5-hydroxymethyl-tetrahydro-furan-3,4-diol

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Technology Process of (2R,3S,4S,5R)-2-(6-Amino-2-phenyl-purin-9-yl)-5-hydroxymethyl-tetrahydro-furan-3,4-diol

There total 7 articles about (2R,3S,4S,5R)-2-(6-Amino-2-phenyl-purin-9-yl)-5-hydroxymethyl-tetrahydro-furan-3,4-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 100-47-0
benzonitrile

: 76054-92-7
5-amino-1-(β-D-arabinofuranosyl)-4-cyanoimidazole

: 125339-07-3
(2R,3S,4S,5R)-2-(6-Amino-2-phenyl-purin-9-yl)-5-hydroxymethyl-tetrahydro-furan-3,4-diol

Guidance literature:: With ammonia; In methanol; at 140 ℃; steel bomb, overnight;
DOI:10.1248/cpb.37.1604

Reference yield:

: 125339-00-6
1-(2-O-acetyl-β-D-arabinofuranosyl)-5-benzylideneamino-4-cyanoimidazole

: 125339-07-3
(2R,3S,4S,5R)-2-(6-Amino-2-phenyl-purin-9-yl)-5-hydroxymethyl-tetrahydro-furan-3,4-diol

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / 80percent acetic acid / H₂O / 2 h / Ambient temperature

2: 81 percent / ammonia / methanol / 3 h / Ambient temperature

3: 62 percent / ammonia / methanol / 140 °C / steel bomb, overnight

With ammonia; acetic acid; In methanol; water;
DOI:10.1248/cpb.37.1604

Reference yield:

: 125338-91-2
5-amino-4-cyano-1-(3,5-O-(tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl)imidazole

: 125339-07-3
(2R,3S,4S,5R)-2-(6-Amino-2-phenyl-purin-9-yl)-5-hydroxymethyl-tetrahydro-furan-3,4-diol

Guidance literature:: Multi-step reaction with 7 steps

1: 94 percent / p-toluenesulfonic acid / benzene / 3 h / Heating

2: 75 percent / 4-dimethylaminopyridine, pyridine / triethylamine / 0.5 h / Ambient temperature

3: 83 percent / dimethylformamide / 48 h / Ambient temperature

4: 73 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 0.08 h / Ambient temperature

5: 80 percent / 80percent acetic acid / H₂O / 2 h / Ambient temperature

6: 81 percent / ammonia / methanol / 3 h / Ambient temperature

7: 62 percent / ammonia / methanol / 140 °C / steel bomb, overnight

With pyridine; dmap; tetrabutyl ammonium fluoride; ammonia; toluene-4-sulfonic acid; acetic acid; In tetrahydrofuran; methanol; water; triethylamine; N,N-dimethyl-formamide; benzene;
DOI:10.1248/cpb.37.1604