2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-cyano-3,3-diphenylpropionic acid ethyl ester

Base Information

Chemical Name:2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-cyano-3,3-diphenylpropionic acid ethyl ester
CAS No.:1314864-22-6
Molecular Formula:C₂₄H₂₃N₃O₃
Molecular Weight:401.465
Hs Code.:

Synonyms:2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-cyano-3,3-diphenylpropionic acid ethyl ester

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Chemical Property of 2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-cyano-3,3-diphenylpropionic acid ethyl ester

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Technology Process of 2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-cyano-3,3-diphenylpropionic acid ethyl ester

There total 2 articles about 2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-cyano-3,3-diphenylpropionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3196-34-7
(+/-)-2-Hydroxy-3,3-diphenyl-bernsteinsaeure-1-ethylester-4-nitril

: 35144-22-0
4,6-dimethyl-2-methylsulfonylpyrimidine

: 1314864-22-6
2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-cyano-3,3-diphenylpropionic acid ethyl ester

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 90 ℃; for 5h;
DOI:10.1016/j.bmcl.2011.05.034

Reference yield:

: 86-29-3
Diphenylacetonitrile

: 1314864-22-6
2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-cyano-3,3-diphenylpropionic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride / tetrahydrofuran; toluene / -20 °C

2: sodium hydride / tetrahydrofuran / 5 h / 90 °C

With sodium hydride; In tetrahydrofuran; toluene;
DOI:10.1016/j.bmcl.2011.05.034