35144-22-0

Basic information

• Product Name: 4,6-Dimethyl-2-methylsulfonylpyrimidine
• Synonyms: VITAS-BB TBB000242;DLMSP;4,6-DIMETHYL-2-METHYLSULFONYLPYRIMIDINE;4,6-DIMETHY-2-METHYLSULFONYLPYRIMIDINE;2-METHANESULFONYL-4,6-DIMETHYL-PYRIMIDINE;4,6-dimethyl-2-mesyl-pyrimidine;4,6-Dimethyl-2-methylsilfonylpyrimidine;4,6-Dimethyl-2-(methylsulfonyl
• CAS NO: 35144-22-0
• Molecular Formula: C₇H₁₀N₂O₂S
• Molecular Weight: 186.23
• EINECS: 1592732-453-0
• Product Categories: Boron, Nitrile, Thio,& TM-Cpds;Heterocycles;Pyrimidines;Drug Intermediates;Heterocycle-Pyrimidine series;Intermediate
• Mol File: 35144-22-0.mol
• Article Data: 6

Chemical Properties

• Melting Point: 84-86°C
• Boiling Point: 358.3 °C at 760 mmHg
• Flash Point: 170.5 °C
• Appearance: Red-brown/Crystalline Solid
• Density: 1.239
• Vapor Pressure: 5.32E-05mmHg at 25°C
• Refractive Index: 1.511
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: -1.84±0.30(Predicted)
• CAS DataBase Reference: 4,6-Dimethyl-2-methylsulfonylpyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4,6-Dimethyl-2-methylsulfonylpyrimidine(35144-22-0)
• EPA Substance Registry System: 4,6-Dimethyl-2-methylsulfonylpyrimidine(35144-22-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• HazardClass: IRRITANT
• Hazardous Substances Data: 35144-22-0(Hazardous Substances Data)

Usage

Chemical Properties

White solid

Uses

4,6-Dimethyl-2-(methylsulfonyl)pyrimidine is a reactant used in the preparation of [(dimethylpyrimidinyl)oxy]diphenyl butyric acid derivatives as endothelin receptor antagonists.

InChI:InChI=1/C7H10N2O2S/c1-5-4-6(2)9-7(8-5)12(3,10)11/h4H,1-3H3

Upstream product

• 22325-27-5 4,6-dimethyl-2-meraptopyrimidine 
• 14001-64-0 4,6-dimethyl-2-methylsulfanyl-pyrimidine 

Downstream Products

• 1240470-84-1 (S)-methyl-2-(4,6-dimethylpyrimidin-2-yloxy)-3-methoxy-3,3-diphenylpropionate 
• 177036-94-1 ambrisentan 
• 1639429-81-4 4,6-dimethyl-2-(2,2-diphenyl-ethenyloxy)pyrimidine 
• 1349854-31-4 (S)-2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenylpropionic acid ethyl ester 
• 177036-94-1 ambrisentan 
• 318472-14-9 (S)-2-(4,6-dimethylpyrimid-2-yloxy)-3,3-diphenylbutyricacid 
• 1394161-64-8 5-m-tolyl-oxazole-4-carboxylic acid {1-[2-(4,6-dimethyl-pyrimidin-2-ylamino)-ethyl]-1H-pyrazol-4-yl}-amide 
• 1007358-76-0 ambrisentan 
• 1386915-48-5 sodium (S)-2-(4,6-dimethylpyrimidin-2-yloxy)-3-methoxy-3,3-diphenylpropanoate 
• 1106685-61-3 (S)-2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenylpropionic acid methyl ester 
• 1314863-85-8 2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-cyano-3,3-diphenylpropionic acid 
• 1314864-22-6 2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-cyano-3,3-diphenylpropionic acid ethyl ester 
• 1314863-90-5 2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3,3-diphenyl butyrrolactone 
• 1314863-86-9 2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3,3,4-triphenyl butyric acid 

Relevant articles and documents

Oxidative kinetic resolution of heterocyclic sulfoxides with a porphyrin-inspired manganese complex by hydrogen peroxide

We have successfully reported here the low loading porphyrin-inspired high-valent manganese (IV)-oxo complex was applied in oxidative kinetic resolution (OKR) of racemic heterocyclic sulfoxides using the environmentally benign hydrogen peroxide for the first time. This approach allows for rapid OKR (0.5 h) of a variety of racemic sulfoxides (including pyridine, pyrimidine, pyrazine, thiazole, benzothiazole, thiophene) in excellent enantioselectivity (up to > 99% ee), simultaneously generating the corresponding sulfones in high yield (up to 80%). The catalytic system also showed an unexceptionable chemoselectivity for the sulfoxide substrates with hydroxyl groups in which only the sulfoxide group was oxidized. The practical utility of the method has been demonstrated in the OKR of gram-scale sulfoxides.

Azinyloxy, and phenoxy-diaryl-carboxylic acid derivatives, their preparation and use as mixed ETA/ETB endothelin receptor antagonists

The invention relates to carboxylic acid derivatives of the formula I where the radicals have the meanings stated in the description, and to their use as drugs.

Herbicidal 2-(phenoxy or phenylthio)-2-(pyrimidinyloxy or 1,3,5-triazinyloxy)-alkanoic acids

2-(Phenoxy or phenylthio)-2-(pyrimidinyloxy or 1,3,5-triazinyloxy)alkanoic acid compounds, such as ethyl 2-(2-fluorophenoxy)-2-(4,6-dimethylpyrimidin-2-yl-oxy)acetate, were prepared by the reaction of a phenol or thiophenol compound with a 2-chloro-2-(pyrimidinyloxy or 1,3,5-triazinyloxy)alkanoate ester compound or by the reaction of a pyrimidinol or 1,3,5-triazinol with a 2-bromo-2-(phenoxy or phenylthio)alkanoate ester. These compounds, and, especially, agriculturally acceptable salts, esters, and amides of these compounds, were found to have herbicidal utility.