(1R,3S)-3-(6-dimethylamino-hexanoylamino)-cyclopentanecarboxylic acid N-(4-benzooxazol-2-ylphenyl)-N-methyl-amide

Base Information

Chemical Name:(1R,3S)-3-(6-dimethylamino-hexanoylamino)-cyclopentanecarboxylic acid N-(4-benzooxazol-2-ylphenyl)-N-methyl-amide
CAS No.:1291779-78-6
Molecular Formula:C₂₈H₃₆N₄O₃
Molecular Weight:476.619
Hs Code.:

Synonyms:(1R,3S)-3-(6-dimethylamino-hexanoylamino)-cyclopentanecarboxylic acid N-(4-benzooxazol-2-ylphenyl)-N-methyl-amide

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Chemical Property of (1R,3S)-3-(6-dimethylamino-hexanoylamino)-cyclopentanecarboxylic acid N-(4-benzooxazol-2-ylphenyl)-N-methyl-amide

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Technology Process of (1R,3S)-3-(6-dimethylamino-hexanoylamino)-cyclopentanecarboxylic acid N-(4-benzooxazol-2-ylphenyl)-N-methyl-amide

There total 5 articles about (1R,3S)-3-(6-dimethylamino-hexanoylamino)-cyclopentanecarboxylic acid N-(4-benzooxazol-2-ylphenyl)-N-methyl-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1291779-79-7
6-(dimethylamino)hexanoic acid hydrobromide

: 1291779-73-1
(1R,3S)-3-amino-cyclopentanecarboxylic acid N-(4-benzooxazol-2-yl-phenyl)-N-methyl-amide trifluoro acetic acid

: 1291779-78-6
(1R,3S)-3-(6-dimethylamino-hexanoylamino)-cyclopentanecarboxylic acid N-(4-benzooxazol-2-ylphenyl)-N-methyl-amide

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In N,N-dimethyl-formamide;

Reference yield:

: 95-55-6
2-amino-phenol

: 1291779-78-6
(1R,3S)-3-(6-dimethylamino-hexanoylamino)-cyclopentanecarboxylic acid N-(4-benzooxazol-2-ylphenyl)-N-methyl-amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: polyphosphoric acid / 4 h / 205 °C

2.1: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 2 h

2.2: 20 °C

3.1: diethylamine / tetrahydrofuran / 20 - 40 °C

4.1: acetonitrile; water

5.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide

With 1-chloro-1-(dimethylamino)-2-methyl-1-propene; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; diethylamine; triethylamine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 2-(p-methylaminophenyl)benzoxazole

: 1291779-78-6
(1R,3S)-3-(6-dimethylamino-hexanoylamino)-cyclopentanecarboxylic acid N-(4-benzooxazol-2-ylphenyl)-N-methyl-amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 2 h

1.2: 20 °C

2.1: diethylamine / tetrahydrofuran / 20 - 40 °C

3.1: acetonitrile; water

4.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide

With 1-chloro-1-(dimethylamino)-2-methyl-1-propene; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; diethylamine; triethylamine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;