17α-[(N-5-azido-2-nitrobenzoyl)amidopropyl]-17β-hydroxy-5α-androstan-3-one

Base Information

Chemical Name:17α-[(N-5-azido-2-nitrobenzoyl)amidopropyl]-17β-hydroxy-5α-androstan-3-one
CAS No.:300351-04-6
Molecular Formula:C₂₉H₃₉N₅O₅
Molecular Weight:537.659
Hs Code.:

Synonyms:17α-[(N-5-azido-2-nitrobenzoyl)amidopropyl]-17β-hydroxy-5α-androstan-3-one

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Chemical Property of 17α-[(N-5-azido-2-nitrobenzoyl)amidopropyl]-17β-hydroxy-5α-androstan-3-one

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Technology Process of 17α-[(N-5-azido-2-nitrobenzoyl)amidopropyl]-17β-hydroxy-5α-androstan-3-one

There total 6 articles about 17α-[(N-5-azido-2-nitrobenzoyl)amidopropyl]-17β-hydroxy-5α-androstan-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 300351-03-5
17α-[(N-5-azido-2-nitrobenzoyl)amidopropyl]-3,3-dimethoxy-5α-androstane-17β-ol

: 300351-04-6
17α-[(N-5-azido-2-nitrobenzoyl)amidopropyl]-17β-hydroxy-5α-androstan-3-one

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 22 ℃; for 4h;
DOI:10.1016/S0039-128X(00)00106-9

Reference yield:

: 846-46-8
androstanedione

: 300351-04-6
17α-[(N-5-azido-2-nitrobenzoyl)amidopropyl]-17β-hydroxy-5α-androstan-3-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: 62 percent / pTsOH*H₂O / 1 h / 40 °C

2.1: 90 percent / potassium t-butoxide / dimethylformamide / 1 h / 22 °C

3.1: LDA / tetrahydrofuran; hexane / -76 °C

3.2: 92 percent / tetrahydrofuran; hexane / 2 h / 22 °C

4.1: 69 percent / LiAlH₄ / tetrahydrofuran / 12 h / 22 °C

5.1: 56 percent / aq. NaHCO₃ / tetrahydrofuran / 24 h / 22 °C

6.1: 95 percent / aq. HCl / dioxane / 4 h / 22 °C

With hydrogenchloride; lithium aluminium tetrahydride; potassium tert-butylate; sodium hydrogencarbonate; toluene-4-sulfonic acid; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; hexane; N,N-dimethyl-formamide;
DOI:10.1016/S0039-128X(00)00106-9

Reference yield:

: 3591-19-3
3,3-(dimethoxy)-5α-androstan-17-one

: 300351-04-6
17α-[(N-5-azido-2-nitrobenzoyl)amidopropyl]-17β-hydroxy-5α-androstan-3-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: 90 percent / potassium t-butoxide / dimethylformamide / 1 h / 22 °C

2.1: LDA / tetrahydrofuran; hexane / -76 °C

2.2: 92 percent / tetrahydrofuran; hexane / 2 h / 22 °C

3.1: 69 percent / LiAlH₄ / tetrahydrofuran / 12 h / 22 °C

4.1: 56 percent / aq. NaHCO₃ / tetrahydrofuran / 24 h / 22 °C

5.1: 95 percent / aq. HCl / dioxane / 4 h / 22 °C

With hydrogenchloride; lithium aluminium tetrahydride; potassium tert-butylate; sodium hydrogencarbonate; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; hexane; N,N-dimethyl-formamide;
DOI:10.1016/S0039-128X(00)00106-9