O-(Acetoacetyl)-N-(9-fluorenylmethoxycarbonyl)-L-serin

Base Information

• Chemical Name: O-(Acetoacetyl)-N-(9-fluorenylmethoxycarbonyl)-L-serin
• CAS No.: 120791-74-4
• Molecular Formula: C₂₂H₂₁NO₇
• Molecular Weight: 411.411
• Mol file: 120791-74-4.mol

Synonyms:O-(Acetoacetyl)-N-(9-fluorenylmethoxycarbonyl)-L-serin

Chemical Property of O-(Acetoacetyl)-N-(9-fluorenylmethoxycarbonyl)-L-serin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of O-(Acetoacetyl)-N-(9-fluorenylmethoxycarbonyl)-L-serin

There total 1 articles about O-(Acetoacetyl)-N-(9-fluorenylmethoxycarbonyl)-L-serin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methyleneoxetan-2-one (674-82-8,2130-41-8) + N-(9H-fluoren-9-ylmethoxycarbonyl)-L-serine (73724-45-5) → O-(Acetoacetyl)-N-(9-fluorenylmethoxycarbonyl)-L-serin (120791-74-4)

Guidance literature:

With triethylamine; In dichloromethane; for 30h; Yield given;

Reference yield:

O-(Acetoacetyl)-N-(9-fluorenylmethoxycarbonyl)-L-serin (120791-74-4) → N-(9-Fluorenylmethoxycarbonyl)-O-<(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-(1->3)-O-(2-acetamido-4,6-di-O-benzoyl-2-desoxy-α-D-galactopyranosyl)>-L-serin-tert-butylester (120204-23-1)

Guidance literature:

Multi-step reaction with 4 steps

1: conc.H₂SO₄ / CH₂Cl₂ / 240 h

2: N₂H₄*H₂O / ethanol / 0.5 h

3: 1.) AgClO₄, molecular sieve / 1.) CH₂Cl₂, toluene, 1 h, -20 deg C; 2.) 2 d

4: 1.) H₂S; 2.) pyridine / 1.) pyridine, H₂O, 0 deg C, 3 h, room temp., 5 h; 2.) 0 deg C, 12 h

With pyridine; molecular sieve; sulfuric acid; hydrogen sulfide; silver perchlorate; hydrazine hydrate; In ethanol; dichloromethane;

Reference yield:

O-(Acetoacetyl)-N-(9-fluorenylmethoxycarbonyl)-L-serin (120791-74-4) → N-(9-Fluorenylmethoxycarbonyl)-O-<(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-(1->3)-O-(2-azido-4,6-di-O-benzoyl-2-desoxy-β-D-galactopyranosyl)>-L-serin-tert-butylester (120851-33-4)

Guidance literature:

Multi-step reaction with 3 steps

1: conc.H₂SO₄ / CH₂Cl₂ / 240 h

2: N₂H₄*H₂O / ethanol / 0.5 h

3: 1.) AgClO₄, molecular sieve / 1.) CH₂Cl₂, toluene, 1 h, -20 deg C; 2.) 2 d

With molecular sieve; sulfuric acid; silver perchlorate; hydrazine hydrate; In ethanol; dichloromethane;

upstream raw materials:

4-methyleneoxetan-2-one

N-(9H-fluoren-9-ylmethoxycarbonyl)-L-serine

Downstream raw materials:

O-(Acetoacetyl)-N-(9-fluorenylmethoxycarbonyl)-L-serin-tert-butylester

N-[(9-fluorenyl)methoxycarbonyl]-L-serine tert-butyl ester

N-(9-Fluorenylmethoxycarbonyl)-O-<(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-(1->3)-O-(2-acetamido-4,6-di-O-benzoyl-2-desoxy-α-D-galactopyranosyl)>-L-serin-tert-butylester

N-(9-Fluorenylmethoxycarbonyl)-O-<(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-(1->3)-O-(2-azido-4,6-di-O-benzoyl-2-desoxy-β-D-galactopyranosyl)>-L-serin-tert-butylester