ethyl N-(trifluoroacetyl)-N-<<2-nitro-5-(2,4-dimethylimidazol-1-yl)phenyl>methyl>glycinate

Base Information

Chemical Name:ethyl N-(trifluoroacetyl)-N-<<2-nitro-5-(2,4-dimethylimidazol-1-yl)phenyl>methyl>glycinate
CAS No.:108857-31-4
Molecular Formula:C₁₈H₁₉F₃N₄O₅
Molecular Weight:428.368
Hs Code.:

Synonyms:ethyl N-(trifluoroacetyl)-N-<<2-nitro-5-(2,4-dimethylimidazol-1-yl)phenyl>methyl>glycinate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl N-(trifluoroacetyl)-N-<<2-nitro-5-(2,4-dimethylimidazol-1-yl)phenyl>methyl>glycinate

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Technology Process of ethyl N-(trifluoroacetyl)-N-<<2-nitro-5-(2,4-dimethylimidazol-1-yl)phenyl>methyl>glycinate

There total 3 articles about ethyl N-(trifluoroacetyl)-N-<<2-nitro-5-(2,4-dimethylimidazol-1-yl)phenyl>methyl>glycinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.0%

: 930-62-1
2,4-Dimethylimidazole

: 108857-30-3
ethyl N-(trifluoroacetyl)-N-<(5-fluoro-2-nitrophenyl)methyl>glycinate

: 108857-31-4
ethyl N-(trifluoroacetyl)-N-<<2-nitro-5-(2,4-dimethylimidazol-1-yl)phenyl>methyl>glycinate

Guidance literature:: With sodium carbonate; In N,N-dimethyl-formamide; at 130 ℃; for 2h;
DOI:10.1021/jm00129a005

Reference yield:

: 82420-35-7
2-(bromomethyl)-4-fluoro-1-nitrobenzene

: 108857-31-4
ethyl N-(trifluoroacetyl)-N-<<2-nitro-5-(2,4-dimethylimidazol-1-yl)phenyl>methyl>glycinate

Guidance literature:: Multi-step reaction with 3 steps

1: 45 percent / ethanol / 1 h / Heating

2: 89 percent / NEt₃ / CH₂Cl₂ / -70 deg C to r.t.

3: 12 percent / Na₂CO₃ / dimethylformamide / 2 h / 130 °C

With sodium carbonate; triethylamine; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00129a005

Reference yield:

: 108857-29-0
ethyl (5-fluoro-2-nitrobenzyl)aminoacetate

: 108857-31-4
ethyl N-(trifluoroacetyl)-N-<<2-nitro-5-(2,4-dimethylimidazol-1-yl)phenyl>methyl>glycinate

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / NEt₃ / CH₂Cl₂ / -70 deg C to r.t.

2: 12 percent / Na₂CO₃ / dimethylformamide / 2 h / 130 °C

With sodium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00129a005