82420-35-7

Basic information

• Product Name: 5-Fluoro-2-nitro benzylbromide
• Synonyms: 5-Fluoro-2-nitro benzylbromide;Benzene, 2-(bromomethyl)-4-fluoro-1-nitro-;2-(Bromomethyl)-4-Fluoro-1-Nitrobenzene(WX630092)
• CAS NO: 82420-35-7
• Molecular Formula: C₇H₅BrFNO₂
• Molecular Weight: 234.0225032
• Mol File: 82420-35-7.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 5-Fluoro-2-nitro benzylbromide(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Fluoro-2-nitro benzylbromide(82420-35-7)
• EPA Substance Registry System: 5-Fluoro-2-nitro benzylbromide(82420-35-7)

Safety Data

• Hazardous Substances Data: 82420-35-7(Hazardous Substances Data)

Usage

General Description

5-Fluoro-2-nitro benzylbromide is a chemical compound with the molecular formula C7H5BrFNO2. It is a derivative of benzylbromide and is characterized by the presence of a nitro group and a fluorine atom on the benzene ring. 5-Fluoro-2-nitro benzylbromide is used in organic synthesis as a building block for the preparation of various biologically active compounds. It is commonly employed in pharmaceutical and agrochemical research for the development of new drugs and pesticides. Additionally, it is utilized as a reagent in the synthesis of complex organic molecules and is known for its ability to undergo nucleophilic substitution reactions. 5-Fluoro-2-nitro benzylbromide is a valuable chemical for the production of diverse chemical compounds with potential applications in the pharmaceutical and agricultural industries.

Upstream product

• 395-81-3 5-fluoro-2-nitrobenzaldehyde 
• 558-13-4 carbon tetrabromide 
• 287121-32-8 (5-Fluoro-2-nitrophenyl)-methanol 
• 446-33-3 5-Fluoro-2-nitrotoluene 

Downstream Products

• 82420-38-0 Ethyl 2-Acetamido-2-(5'-fluoro-2'-nitrobenzyl)malonate 
• 223787-45-9 diethyl (5-fluoro-2-nitrophenyl)methylphosphonate 
• 1644-82-2 2-fluoro-6-nitrobenzaldehyde 
• 108857-29-0 ethyl (5-fluoro-2-nitrobenzyl)aminoacetate 
• 287121-34-0 methyl 2-{(5-fluoro-2-nitrobenzyl)[(4-methoxyphenyl)sulfonyl]amino}-3-hydroxypropanoate 
• 1356349-77-3 (2S)-1-cyclopentyl-N-(5-fluoro-2-nitrobenzyl)propan-2-amine 
• 1356349-83-1 tert-butyl [(2S)-1-cyclopentylpropan-2-yl](5-fluoro-2-{[(8-fluoro-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-6-yl)sulfonyl]amino}benzyl)carbamate 
• 1356349-81-9 tert-butyl (2-amino-5-fluorobenzyl)[(2S)-1-cyclopentylpropan-2-yl]carbamate 
• 1356349-79-5 tert-butyl [(2S)-1-cyclopentylpropan-2-yl](5-fluoro-2-nitrobenzyl)carbamate 
• 1356349-42-2 N-[2-({[(2S)-1-cyclopentylpropan-2-yl]amino}methyl)-4-fluorophenyl]-8-fluoro-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-6-sulfonamide 
• 395-81-3 5-fluoro-2-nitrobenzaldehyde 
• 1269632-28-1 (2E)-methyl 3-(2-(5-fluoro-2-nitrostyryl)-1-phenylsulfonylindol-3-yl)but-2-enoate 
• 1202772-31-3 1-Fluoro-2-[(methylsulfanyl)methyl]-3-nitrobenzene 
• 925449-98-5 1-(5-fluoro-2-nitrobenzylsulfonyl)naphthalene 

Relevant articles and documents

Intramolecular Pd-catalyzed reductive amination of enolizable sp3-C-H bonds

A palladium-catalyzed reductive cyclization of nitroarenes has been designed to construct sp3-C-NHAr bonds from sp3-C-H bonds by using an enolizable nucleophile to intercept a nitrosoarene intermediate. Exposure of ortho-substituted nitroarenes to 5 mol ?% of Pd(OAc)2 and 10 mol ?% of phenanthroline under 2 atm of CO constructs partially saturated 5-, 6-, or 7-membered N-heterocycles using α-pyridyl carboxylates, malonates, 1,3-dimethylbarbituric acid, 1,3-diones, or difurans as the nucleophile.

Synthetic studies on indolocarbazoles: Total synthesis of staurosporine aglycon

A synthesis of staurosporine aglycon and its analogs was achieved in a 28-36% overall yield starting from 2-methylindole. The prominent key steps for the synthesis of the indolocarbazole alkaloids involved electrocyclization and nitrene insertion reactions.

SUBSTITUTED 7-SULFANYLMETHYL-, 7-SULFINYLMETHYL- AND 7-SULFONYLMETHYLINDOLES AND THE USE THEREOF

The present application relates to novel 7-sulfanylmethyl-, 7-sulfinylmethyl- and 7-sulfonylmethylindole derivatives, processes for the preparation thereof, the use thereof alone or in combinations for the treatment and/or prevention of diseases, and the use thereof for the manufacture of medicaments for the treatment and/or prevention of diseases, especially for the treatment and/or prevention of cardiovascular disorders.