(S)-2-Amino-3-benzyloxy-propionic acid benzyl ester; compound with trifluoro-acetic acid

Base Information

• Chemical Name: (S)-2-Amino-3-benzyloxy-propionic acid benzyl ester; compound with trifluoro-acetic acid
• CAS No.: 67321-06-6
• Molecular Formula: C₂HF₃O₂*C₁₇H₁₉NO₃
• Molecular Weight: 399.367
• Mol file: 67321-06-6.mol

Synonyms:(S)-2-Amino-3-benzyloxy-propionic acid benzyl ester; compound with trifluoro-acetic acid

Chemical Property of (S)-2-Amino-3-benzyloxy-propionic acid benzyl ester; compound with trifluoro-acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of (S)-2-Amino-3-benzyloxy-propionic acid benzyl ester; compound with trifluoro-acetic acid

There total 3 articles about (S)-2-Amino-3-benzyloxy-propionic acid benzyl ester; compound with trifluoro-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-benzyl 3-(benzyloxy)-2-((tert-butoxycarbonyl)amino)propanoate (69871-79-0) + trifluoroacetic acid (76-05-1) → (S)-2-Amino-3-benzyloxy-propionic acid benzyl ester; compound with trifluoro-acetic acid (67321-06-6)

Guidance literature:

In dichloromethane; for 0.5h; Ambient temperature;

Reference yield:

BOC-O-benzyl-L-serine (23680-31-1) → (S)-2-Amino-3-benzyloxy-propionic acid benzyl ester; compound with trifluoro-acetic acid (67321-06-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / 1M caesium hydroxide / 1) ethanol, 5 deg C; 2) DMF, 3 h

2: CH₂Cl₂ / 0.5 h / Ambient temperature

With cesium hydroxide; In dichloromethane;

Reference yield:

benzyl bromide (100-39-0) → (S)-2-Amino-3-benzyloxy-propionic acid benzyl ester; compound with trifluoro-acetic acid (67321-06-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / 1M caesium hydroxide / 1) ethanol, 5 deg C; 2) DMF, 3 h

2: CH₂Cl₂ / 0.5 h / Ambient temperature

With cesium hydroxide; In dichloromethane;

upstream raw materials:

(S)-benzyl 3-(benzyloxy)-2-((tert-butoxycarbonyl)amino)propanoate

trifluoroacetic acid

BOC-O-benzyl-L-serine

benzyl bromide

Downstream raw materials:

N^α-t-butoxycarbonyl-O-benzyltyrosyl-O-benzylserine benzyl ester