2-(4-methyl-1H-imidazol-1-yl)-1-[2-[(tert-butoxycarbonyl)-amino]phenyl]ethane

Base Information

• Chemical Name: 2-(4-methyl-1H-imidazol-1-yl)-1-[2-[(tert-butoxycarbonyl)-amino]phenyl]ethane
• CAS No.: 892393-33-8
• Molecular Formula: C₁₇H₂₃N₃O₂
• Molecular Weight: 301.389
• Mol file: 892393-33-8.mol

Synonyms:2-(4-methyl-1H-imidazol-1-yl)-1-[2-[(tert-butoxycarbonyl)-amino]phenyl]ethane

Chemical Property of 2-(4-methyl-1H-imidazol-1-yl)-1-[2-[(tert-butoxycarbonyl)-amino]phenyl]ethane

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 2-(4-methyl-1H-imidazol-1-yl)-1-[2-[(tert-butoxycarbonyl)-amino]phenyl]ethane

There total 1 articles about 2-(4-methyl-1H-imidazol-1-yl)-1-[2-[(tert-butoxycarbonyl)-amino]phenyl]ethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4-methyl-1H-imidazole (822-36-6) + 2-(mesyloxy)-1-[2-[(tert-butoxycarbonyl)amino]phenyl]ethane (193806-50-7) → 2-(5-methyl-1H-imidazol-1-yl)-1-[2-[(tert-butoxycarbonyl)-amino]phenyl]ethane (892393-34-9) + 2-(4-methyl-1H-imidazol-1-yl)-1-[2-[(tert-butoxycarbonyl)-amino]phenyl]ethane (892393-33-8) + 1-(tert-butoxycarbonyl)indoline (143262-10-6)

Guidance literature:

4-methyl-1H-imidazole; With sodium hydride; In N,N-dimethyl-formamide; at 25 ℃; for 0.5h;

2-(mesyloxy)-1-[2-[(tert-butoxycarbonyl)amino]phenyl]ethane; In N,N-dimethyl-formamide; at 25 ℃; for 2.5h; Product distribution / selectivity;

Reference yield: 94.0%

2-(4-methyl-1H-imidazol-1-yl)-1-[2-[(tert-butoxycarbonyl)-amino]phenyl]ethane (892393-33-8) → 1-(2-aminophenyl)-2-(4-methyl-1H-imidazol-1-yl)ethane (892393-31-6)

Guidance literature:

With sulfuric acid; In 1,4-dioxane; methanol; at 25 ℃; for 4h;

Reference yield:

2-(5-methyl-1H-imidazol-1-yl)-1-[2-[(tert-butoxycarbonyl)-amino]phenyl]ethane (892393-34-9) + 2-(4-methyl-1H-imidazol-1-yl)-1-[2-[(tert-butoxycarbonyl)-amino]phenyl]ethane (892393-33-8) + trityl chloride (76-83-5) → C17H23N3O2*C19H15Cl (892393-35-0) + C17H23N3O2*C19H15Cl (892393-36-1)

Guidance literature:

In dichloromethane; at 0 ℃; for 2h;

upstream raw materials:

4-methyl-1H-imidazole

2-(mesyloxy)-1-[2-[(tert-butoxycarbonyl)amino]phenyl]ethane

Downstream raw materials:

C₁₇H₂₃N₃O₂*C₁₉H₁₅Cl

C₁₇H₂₃N₃O₂*C₁₉H₁₅Cl

1-(2-aminophenyl)-2-(4-methyl-1H-imidazol-1-yl)ethane