(9H-fluoren-9-yl)methyl (S)-1-((S)-1-hydroxy-3-phenylpropan-2-ylamino)-3-methyl-1-oxobutan-2-ylcarbamate

Base Information

• Chemical Name: (9H-fluoren-9-yl)methyl (S)-1-((S)-1-hydroxy-3-phenylpropan-2-ylamino)-3-methyl-1-oxobutan-2-ylcarbamate
• CAS No.: 1228823-06-0
• Molecular Formula: C₂₉H₃₂N₂O₄
• Molecular Weight: 472.584

Synonyms:(9H-fluoren-9-yl)methyl (S)-1-((S)-1-hydroxy-3-phenylpropan-2-ylamino)-3-methyl-1-oxobutan-2-ylcarbamate

Chemical Property of (9H-fluoren-9-yl)methyl (S)-1-((S)-1-hydroxy-3-phenylpropan-2-ylamino)-3-methyl-1-oxobutan-2-ylcarbamate

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Technology Process of (9H-fluoren-9-yl)methyl (S)-1-((S)-1-hydroxy-3-phenylpropan-2-ylamino)-3-methyl-1-oxobutan-2-ylcarbamate

There total 1 articles about (9H-fluoren-9-yl)methyl (S)-1-((S)-1-hydroxy-3-phenylpropan-2-ylamino)-3-methyl-1-oxobutan-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

Fmoc-Val-OH (68858-20-8) + L-Phenylalaninol (3182-95-4) → (9H-fluoren-9-yl)methyl (S)-1-((S)-1-hydroxy-3-phenylpropan-2-ylamino)-3-methyl-1-oxobutan-2-ylcarbamate (1228823-06-0)

Guidance literature:

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 6h;

DOI:10.1016/j.ejmech.2010.02.035

Reference yield: 62.0%

(9H-fluoren-9-yl)methyl (S)-1-((S)-1-hydroxy-3-phenylpropan-2-ylamino)-3-methyl-1-oxobutan-2-ylcarbamate (1228823-06-0) + benzoic acid anhydride (93-97-0) → (S)-2-((S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-methylbutanamido)-3-phenylpropyl benzoate (1228823-17-3)

Guidance literature:

With pyridine; at 20 ℃; for 6h;

DOI:10.1016/j.ejmech.2010.02.035

Reference yield:

(9H-fluoren-9-yl)methyl (S)-1-((S)-1-hydroxy-3-phenylpropan-2-ylamino)-3-methyl-1-oxobutan-2-ylcarbamate (1228823-06-0) + acetic anhydride (108-24-7) → (S)-2-((S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-methylbutanamido)-3-phenylpropyl acetate (1228822-97-6)

Guidance literature:

With pyridine; at 20 ℃; for 1h;

DOI:10.1016/j.ejmech.2008.11.008

upstream raw materials:

Fmoc-Val-OH

L-Phenylalaninol

Downstream raw materials:

(S)-2-((S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-methylbutanamido)-3-phenylpropyl acetate

(S)-2-((S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-methylbutanamido)-3-phenylpropyl benzoate

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