Z-5-(Ethoxycarbonyl)methylene-5,6-dihydro-3-(p-methoxyphenyl)-4H-1,2,4-oxadiazine

Base Information

• Chemical Name: Z-5-(Ethoxycarbonyl)methylene-5,6-dihydro-3-(p-methoxyphenyl)-4H-1,2,4-oxadiazine
• CAS No.: 85322-17-4
• Molecular Formula: C₁₄H₁₆N₂O₄
• Molecular Weight: 276.292

Synonyms:Z-5-(Ethoxycarbonyl)methylene-5,6-dihydro-3-(p-methoxyphenyl)-4H-1,2,4-oxadiazine

Chemical Property of Z-5-(Ethoxycarbonyl)methylene-5,6-dihydro-3-(p-methoxyphenyl)-4H-1,2,4-oxadiazine

Chemical Property:

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Technology Process of Z-5-(Ethoxycarbonyl)methylene-5,6-dihydro-3-(p-methoxyphenyl)-4H-1,2,4-oxadiazine

There total 1 articles about Z-5-(Ethoxycarbonyl)methylene-5,6-dihydro-3-(p-methoxyphenyl)-4H-1,2,4-oxadiazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 4.1%

4-bromoethyl acetoacetate (13176-46-0) + 4-methoxybenzamidoxime (5373-87-5) → Z-5-(Ethoxycarbonyl)methylene-5,6-dihydro-3-(p-methoxyphenyl)-4H-1,2,4-oxadiazine (85322-17-4) + [3-(4-Methoxy-phenyl)-4H-[1,2,4]oxadiazin-(5E)-ylidene]-acetic acid ethyl ester (85322-29-8)

Guidance literature:

With toluene-4-sulfonic acid; In acetonitrile; for 3h; Heating;

Reference yield: 74.0%

Z-5-(Ethoxycarbonyl)methylene-5,6-dihydro-3-(p-methoxyphenyl)-4H-1,2,4-oxadiazine (85322-17-4) → [2-(4-Methoxy-phenyl)-oxazol-4-yl]-acetic acid ethyl ester (84446-02-6) + 6-Hydroxymethyl-2-p-methoxyphenyl-4-pyrimidinone (84446-01-5)

Guidance literature:

With hydrogen; nickel; In tetrahydrofuran; for 72h; under 760 Torr; Ambient temperature;

Reference yield: 42.2%

Z-5-(Ethoxycarbonyl)methylene-5,6-dihydro-3-(p-methoxyphenyl)-4H-1,2,4-oxadiazine (85322-17-4) → [2-(4-Methoxy-phenyl)-oxazol-4-yl]-acetic acid ethyl ester (84446-02-6) + 6-Hydroxymethyl-2-(4-methoxy-phenyl)-pyrimidin-4-ol (84446-01-5)

Guidance literature:

With hydrogen; Ni-Ra; In tetrahydrofuran; for 72h; under 760 Torr; Ambient temperature;

upstream raw materials:

4-bromoethyl acetoacetate

4-methoxybenzamidoxime

Downstream raw materials:

[2-(4-Methoxy-phenyl)-oxazol-4-yl]-acetic acid ethyl ester

6-Hydroxymethyl-2-p-methoxyphenyl-4-pyrimidinone

6-Hydroxymethyl-2-(4-methoxy-phenyl)-pyrimidin-4-ol

3-[(E)-N-Hydroxy-4-methoxy-benzimidoylimino]-butyric acid ethyl ester

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