ethyl 4-{6-[adamantan-1-ylmethyl]-2,6-diazabicyclo[3.2.1]oct-2-yl}benzoate

Base Information

Chemical Name:ethyl 4-{6-[adamantan-1-ylmethyl]-2,6-diazabicyclo[3.2.1]oct-2-yl}benzoate
CAS No.:1335145-67-9
Molecular Formula:C₂₆H₃₆N₂O₂
Molecular Weight:408.584
Hs Code.:

Synonyms:ethyl 4-{6-[adamantan-1-ylmethyl]-2,6-diazabicyclo[3.2.1]oct-2-yl}benzoate

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Chemical Property of ethyl 4-{6-[adamantan-1-ylmethyl]-2,6-diazabicyclo[3.2.1]oct-2-yl}benzoate

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Technology Process of ethyl 4-{6-[adamantan-1-ylmethyl]-2,6-diazabicyclo[3.2.1]oct-2-yl}benzoate

There total 5 articles about ethyl 4-{6-[adamantan-1-ylmethyl]-2,6-diazabicyclo[3.2.1]oct-2-yl}benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1335145-66-8
ethyl 4-{6-[adamantan-1-ylcarbonyl]-2,6-diazabicyclo[3.2.1]oct-2-yl}benzoate

: 1335145-67-9
ethyl 4-{6-[adamantan-1-ylmethyl]-2,6-diazabicyclo[3.2.1]oct-2-yl}benzoate

Guidance literature:: ethyl 4-{6-[adamantan-1-ylcarbonyl]-2,6-diazabicyclo[3.2.1]oct-2-yl}benzoate; With borane-THF; In tetrahydrofuran; at 70 ℃; for 1h;

With hydrogenchloride; In ethanol; water; at 20 - 70 ℃; for 2h;

With sodium carbonate; In water; ethyl acetate; at 20 ℃;

Reference yield:

: 1335145-65-7
ethyl 4-(2,6-diazabicyclo[3.2.1]octan-2-yl)benzoate

: 1335145-67-9
ethyl 4-{6-[adamantan-1-ylmethyl]-2,6-diazabicyclo[3.2.1]oct-2-yl}benzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dmap / dichloromethane / 20 °C

2.1: borane-THF / tetrahydrofuran / 1 h / 70 °C

2.2: 2 h / 20 - 70 °C

2.3: 20 °C

With borane-THF; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; In tetrahydrofuran; dichloromethane;

Reference yield:

: 286946-67-6
benzyl 2,6-diazabicyclo[3.2.1]-octane-6-carboxylate

: 1335145-67-9
ethyl 4-{6-[adamantan-1-ylmethyl]-2,6-diazabicyclo[3.2.1]oct-2-yl}benzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / dimethyl sulfoxide / 130 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 3 h

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dmap / dichloromethane / 20 °C

4.1: borane-THF / tetrahydrofuran / 1 h / 70 °C

4.2: 2 h / 20 - 70 °C

4.3: 20 °C

With borane-THF; hydrogen; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide;