[R-(E)]-3-[6-methoxy-1-(4-methoxyphenyl)-2-naphthalenyl]-N-[1-methyl-4-(3-pyridinyl)butyl]-2-propenamide

Base Information

Chemical Name:[R-(E)]-3-[6-methoxy-1-(4-methoxyphenyl)-2-naphthalenyl]-N-[1-methyl-4-(3-pyridinyl)butyl]-2-propenamide
CAS No.:121457-74-7
Molecular Formula:C₃₁H₃₂N₂O₃
Molecular Weight:480.607
Hs Code.:

Synonyms:[R-(E)]-3-[6-methoxy-1-(4-methoxyphenyl)-2-naphthalenyl]-N-[1-methyl-4-(3-pyridinyl)butyl]-2-propenamide

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Chemical Property of [R-(E)]-3-[6-methoxy-1-(4-methoxyphenyl)-2-naphthalenyl]-N-[1-methyl-4-(3-pyridinyl)butyl]-2-propenamide

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Technology Process of [R-(E)]-3-[6-methoxy-1-(4-methoxyphenyl)-2-naphthalenyl]-N-[1-methyl-4-(3-pyridinyl)butyl]-2-propenamide

There total 11 articles about [R-(E)]-3-[6-methoxy-1-(4-methoxyphenyl)-2-naphthalenyl]-N-[1-methyl-4-(3-pyridinyl)butyl]-2-propenamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.8%

: 111954-72-4
(R)-α-methyl-3-pyridinebutanamine

: 121458-01-3
(E)-3-[6-methoxy-1-(4-methoxyphenyl)-2-naphthalenyl]-2-propenoic acid 4-nitrophenyl ester

: 121457-74-7
[R-(E)]-3-[6-methoxy-1-(4-methoxyphenyl)-2-naphthalenyl]-N-[1-methyl-4-(3-pyridinyl)butyl]-2-propenamide

Guidance literature:: In tetrahydrofuran; for 42h; Ambient temperature;
DOI:10.1021/jm00172a029

Reference yield:

: 104-92-7
1-bromo-4-methoxy-benzene

: 121457-74-7
[R-(E)]-3-[6-methoxy-1-(4-methoxyphenyl)-2-naphthalenyl]-N-[1-methyl-4-(3-pyridinyl)butyl]-2-propenamide

Guidance literature:: Multi-step reaction with 9 steps

1: 1.) magnesium / 1.) THF, 2.) RT, 2 h

2: p-toluenesulfonic acid / toluene / 3 h / Heating

3: dimethylformamide / 1.5 h / 35 °C

4: 10 N aq. NaOH / dimethylformamide / 0.17 h / 110 °C

5: DDQ / benzene / 17 h / Heating

6: CH₂Cl₂ / 40 h / Ambient temperature

7: 2 N aq. NaOH / methanol / 1 h / Heating

8: 83.4 percent / dicyclohexylcarbodiimide / CH₂Cl₂ / Ambient temperature

9: 78.8 percent / tetrahydrofuran / 42 h / Ambient temperature

With sodium hydroxide; toluene-4-sulfonic acid; magnesium; dicyclohexyl-carbodiimide; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene; benzene;
DOI:10.1021/jm00172a029

Reference yield:

: 79822-57-4
7-methoxy-4-(4-methoxyphenyl)-1,2-dihydronaphthalene

: 121457-74-7
[R-(E)]-3-[6-methoxy-1-(4-methoxyphenyl)-2-naphthalenyl]-N-[1-methyl-4-(3-pyridinyl)butyl]-2-propenamide

Guidance literature:: Multi-step reaction with 7 steps

1: dimethylformamide / 1.5 h / 35 °C

2: 10 N aq. NaOH / dimethylformamide / 0.17 h / 110 °C

3: DDQ / benzene / 17 h / Heating

4: CH₂Cl₂ / 40 h / Ambient temperature

5: 2 N aq. NaOH / methanol / 1 h / Heating

6: 83.4 percent / dicyclohexylcarbodiimide / CH₂Cl₂ / Ambient temperature

7: 78.8 percent / tetrahydrofuran / 42 h / Ambient temperature

With sodium hydroxide; dicyclohexyl-carbodiimide; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm00172a029