(E)-3-[6-methoxy-1-(4-methoxyphenyl)-2-naphthalenyl]-2-propenoic acid 4-nitrophenyl ester

Base Information

Chemical Name:(E)-3-[6-methoxy-1-(4-methoxyphenyl)-2-naphthalenyl]-2-propenoic acid 4-nitrophenyl ester
CAS No.:121458-01-3
Molecular Formula:C₂₇H₂₁NO₆
Molecular Weight:455.467
Hs Code.:

Synonyms:(E)-3-[6-methoxy-1-(4-methoxyphenyl)-2-naphthalenyl]-2-propenoic acid 4-nitrophenyl ester

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Chemical Property of (E)-3-[6-methoxy-1-(4-methoxyphenyl)-2-naphthalenyl]-2-propenoic acid 4-nitrophenyl ester

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Technology Process of (E)-3-[6-methoxy-1-(4-methoxyphenyl)-2-naphthalenyl]-2-propenoic acid 4-nitrophenyl ester

There total 10 articles about (E)-3-[6-methoxy-1-(4-methoxyphenyl)-2-naphthalenyl]-2-propenoic acid 4-nitrophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.4%

: 100-02-7,78813-13-5,89830-32-0
4-nitro-phenol

: 121458-00-2
(E)-3-[6-methoxy-1-(4-methoxyphenyl)-2-naphthalenyl]-2-propenoic acid

: 121458-01-3
(E)-3-[6-methoxy-1-(4-methoxyphenyl)-2-naphthalenyl]-2-propenoic acid 4-nitrophenyl ester

Guidance literature:: With dicyclohexyl-carbodiimide; In dichloromethane; Ambient temperature;
DOI:10.1021/jm00172a029

Reference yield:

: 104-92-7
1-bromo-4-methoxy-benzene

: 121458-01-3
(E)-3-[6-methoxy-1-(4-methoxyphenyl)-2-naphthalenyl]-2-propenoic acid 4-nitrophenyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) magnesium / 1.) THF, 2.) RT, 2 h

2: p-toluenesulfonic acid / toluene / 3 h / Heating

3: dimethylformamide / 1.5 h / 35 °C

4: 10 N aq. NaOH / dimethylformamide / 0.17 h / 110 °C

5: DDQ / benzene / 17 h / Heating

6: CH₂Cl₂ / 40 h / Ambient temperature

7: 2 N aq. NaOH / methanol / 1 h / Heating

8: 83.4 percent / dicyclohexylcarbodiimide / CH₂Cl₂ / Ambient temperature

With sodium hydroxide; toluene-4-sulfonic acid; magnesium; dicyclohexyl-carbodiimide; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene; benzene;
DOI:10.1021/jm00172a029

Reference yield:

: 79822-57-4
7-methoxy-4-(4-methoxyphenyl)-1,2-dihydronaphthalene

: 121458-01-3
(E)-3-[6-methoxy-1-(4-methoxyphenyl)-2-naphthalenyl]-2-propenoic acid 4-nitrophenyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: dimethylformamide / 1.5 h / 35 °C

2: 10 N aq. NaOH / dimethylformamide / 0.17 h / 110 °C

3: DDQ / benzene / 17 h / Heating

4: CH₂Cl₂ / 40 h / Ambient temperature

5: 2 N aq. NaOH / methanol / 1 h / Heating

6: 83.4 percent / dicyclohexylcarbodiimide / CH₂Cl₂ / Ambient temperature

With sodium hydroxide; dicyclohexyl-carbodiimide; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In methanol; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm00172a029