5-(fluoromethoxy-d₂)-1-{2-fluoro-4-(tetrahydro-2H-pyran-4-yl)phenyl}-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one

Base Information

• Chemical Name: 5-(fluoromethoxy-d₂)-1-{2-fluoro-4-(tetrahydro-2H-pyran-4-yl)phenyl}-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one
• CAS No.: 1425937-12-7
• Molecular Formula: C₂₅H₂₂F₂N₄O₃
• Molecular Weight: 466.456

Synonyms:5-(fluoromethoxy-d₂)-1-{2-fluoro-4-(tetrahydro-2H-pyran-4-yl)phenyl}-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one

Chemical Property of 5-(fluoromethoxy-d₂)-1-{2-fluoro-4-(tetrahydro-2H-pyran-4-yl)phenyl}-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one

Chemical Property:

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Technology Process of 5-(fluoromethoxy-d₂)-1-{2-fluoro-4-(tetrahydro-2H-pyran-4-yl)phenyl}-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one

There total 8 articles about 5-(fluoromethoxy-d₂)-1-{2-fluoro-4-(tetrahydro-2H-pyran-4-yl)phenyl}-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

fluoroiodomethane-d2 (1392190-44-1) + 1-[2-fluoro-4-(tetrahydro-2H-pyran-4-yl)phenyl]-5-hydroxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one (1425937-23-0) → 5-(fluoromethoxy-d2)-1-{2-fluoro-4-(tetrahydro-2H-pyran-4-yl)phenyl}-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one (1425937-12-7)

Guidance literature:

1-[2-fluoro-4-(tetrahydro-2H-pyran-4-yl)phenyl]-5-hydroxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.0833333h; Inert atmosphere;

fluoroiodomethane-d₂ ; In N,N-dimethyl-formamide; at 0 - 35 ℃; for 2.66667h; Inert atmosphere;

Reference yield:

1-(benzyloxy)-2,4-pentanedione (75329-65-6) → 5-(fluoromethoxy-d2)-1-{2-fluoro-4-(tetrahydro-2H-pyran-4-yl)phenyl}-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one (1425937-12-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: hydrogenchloride; sodium nitrite / water / Cooling with ice

1.2: 3 h / 0 - 35 °C

2.1: N,N-dimethyl-formamide / 5 h / 80 °C

2.2: 0 - 35 °C

3.1: hydrogen bromide; acetic acid / 12 h / 50 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 0.08 h / 0 °C / Inert atmosphere

4.2: 2.67 h / 0 - 35 °C / Inert atmosphere

With hydrogenchloride; hydrogen bromide; sodium hydride; acetic acid; sodium nitrite; In water; N,N-dimethyl-formamide;

Reference yield:

2-fluro-4-iodoaniline (29632-74-4) → 5-(fluoromethoxy-d2)-1-{2-fluoro-4-(tetrahydro-2H-pyran-4-yl)phenyl}-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one (1425937-12-7)

Guidance literature:

Multi-step reaction with 6 steps

1.1: palladium diacetate; caesium carbonate; XPhos / 1,2-dimethoxyethane; water / 12 h / 90 °C / Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen / ethanol / 5 h / 10 - 35 °C

3.1: hydrogenchloride; sodium nitrite / water / Cooling with ice

3.2: 3 h / 0 - 35 °C

4.1: N,N-dimethyl-formamide / 5 h / 80 °C

4.2: 0 - 35 °C

5.1: hydrogen bromide; acetic acid / 12 h / 50 °C

6.1: sodium hydride / N,N-dimethyl-formamide / 0.08 h / 0 °C / Inert atmosphere

6.2: 2.67 h / 0 - 35 °C / Inert atmosphere

With hydrogenchloride; palladium 10% on activated carbon; hydrogen bromide; hydrogen; palladium diacetate; sodium hydride; caesium carbonate; acetic acid; sodium nitrite; XPhos; In 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide;

upstream raw materials:

fluoroiodomethane-d₂

1-[2-fluoro-4-(tetrahydro-2H-pyran-4-yl)phenyl]-5-hydroxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one

1-(benzyloxy)-2,4-pentanedione

2-fluro-4-iodoaniline

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