1-(tert-butoxycarbonyl)-N-[5-chloro-2-(1H-tetrazol-1-yl)benzyl]-4,4-difluoro-L-prolinamide

Base Information

• Chemical Name: 1-(tert-butoxycarbonyl)-N-[5-chloro-2-(1H-tetrazol-1-yl)benzyl]-4,4-difluoro-L-prolinamide
• CAS No.: 681128-16-5
• Molecular Formula: C₁₈H₂₁ClF₂N₆O₃
• Molecular Weight: 442.853
• Mol file: 681128-16-5.mol

Synonyms:1-(tert-butoxycarbonyl)-N-[5-chloro-2-(1H-tetrazol-1-yl)benzyl]-4,4-difluoro-L-prolinamide

Chemical Property of 1-(tert-butoxycarbonyl)-N-[5-chloro-2-(1H-tetrazol-1-yl)benzyl]-4,4-difluoro-L-prolinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(tert-butoxycarbonyl)-N-[5-chloro-2-(1H-tetrazol-1-yl)benzyl]-4,4-difluoro-L-prolinamide

There total 1 articles about 1-(tert-butoxycarbonyl)-N-[5-chloro-2-(1H-tetrazol-1-yl)benzyl]-4,4-difluoro-L-prolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

1-(tert-butoxycarbonyl)-4,4-difluoro-L-proline (203866-15-3) + 5-Chloro-2-tetrazol-1-yl-benzylamine (449756-95-0) → 1-(tert-butoxycarbonyl)-N-[5-chloro-2-(1H-tetrazol-1-yl)benzyl]-4,4-difluoro-L-prolinamide (681128-16-5)

Guidance literature:

With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

DOI:10.1016/j.bmc.2006.06.040

Reference yield: 98.0%

1-(tert-butoxycarbonyl)-N-[5-chloro-2-(1H-tetrazol-1-yl)benzyl]-4,4-difluoro-L-prolinamide (681128-16-5) → N-[5-chloro-2-(1H-tetrazol-1-yl)benzyl]-4,4-difluoro-L-prolinamide dihydrochloride

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; ethyl acetate; at 20 ℃;

DOI:10.1016/j.bmc.2006.06.040

Reference yield:

1-(tert-butoxycarbonyl)-N-[5-chloro-2-(1H-tetrazol-1-yl)benzyl]-4,4-difluoro-L-prolinamide (681128-16-5) → [(R)-2-[(S)-2-(5-Chloro-2-tetrazol-1-yl-benzylcarbamoyl)-4,4-difluoro-pyrrolidin-1-yl]-1-(1-methyl-cyclopropylmethyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester (681128-24-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / HCl / ethyl acetate; dioxane / 20 °C

2: 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide HCl; 1-hydroxy-7-aza-1H-benzotriazole; Huenig's base / dimethylformamide / 18 h / 20 °C / pH 6 - 8

With hydrogenchloride; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2006.06.040

upstream raw materials:

1-(tert-butoxycarbonyl)-4,4-difluoro-L-proline

5-Chloro-2-tetrazol-1-yl-benzylamine

Downstream raw materials:

[(R)-2-[(S)-2-(5-Chloro-2-tetrazol-1-yl-benzylcarbamoyl)-4,4-difluoro-pyrrolidin-1-yl]-1-(1-methyl-cyclopropylmethyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester