L-Prolinamide, N-[(1,1-dimethylethoxy)carbonyl]-3-(1-methylcyclopropyl)-D-alanyl-N-[[5- chloro-2-(1H-tetrazol-1-yl)phenyl]methyl]-4,4-difluoro-

Base Information

Chemical Name:L-Prolinamide, N-[(1,1-dimethylethoxy)carbonyl]-3-(1-methylcyclopropyl)-D-alanyl-N-[[5- chloro-2-(1H-tetrazol-1-yl)phenyl]methyl]-4,4-difluoro-
CAS No.:681128-24-5
Molecular Formula:C₂₅H₃₂ClF₂N₇O₄
Molecular Weight:568.023
Hs Code.:

L-Prolinamide,
N-[(1,1-dimethylethoxy)carbonyl]-3-(1-methylcyclopropyl)-D-alanyl-N-[[5-
chloro-2-(1H-tetrazol-1-yl)phenyl]methyl]-4,4-difluoro-

Synonyms:

Suppliers and Price of L-Prolinamide, N-[(1,1-dimethylethoxy)carbonyl]-3-(1-methylcyclopropyl)-D-alanyl-N-[[5- chloro-2-(1H-tetrazol-1-yl)phenyl]methyl]-4,4-difluoro-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of L-Prolinamide, N-[(1,1-dimethylethoxy)carbonyl]-3-(1-methylcyclopropyl)-D-alanyl-N-[[5- chloro-2-(1H-tetrazol-1-yl)phenyl]methyl]-4,4-difluoro-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of L-Prolinamide, N-[(1,1-dimethylethoxy)carbonyl]-3-(1-methylcyclopropyl)-D-alanyl-N-[[5- chloro-2-(1H-tetrazol-1-yl)phenyl]methyl]-4,4-difluoro-

There total 7 articles about L-Prolinamide, N-[(1,1-dimethylethoxy)carbonyl]-3-(1-methylcyclopropyl)-D-alanyl-N-[[5- chloro-2-(1H-tetrazol-1-yl)phenyl]methyl]-4,4-difluoro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 681128-23-4
N-(tert-butoxycarbonyl)-3-(1-methylcyclopropyl)-D-alanine

: N-[5-chloro-2-(1H-tetrazol-1-yl)benzyl]-4,4-difluoro-L-prolinamide dihydrochloride

: 681128-24-5
[(R)-2-[(S)-2-(5-Chloro-2-tetrazol-1-yl-benzylcarbamoyl)-4,4-difluoro-pyrrolidin-1-yl]-1-(1-methyl-cyclopropylmethyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 18h; pH=6 - 8;
DOI:10.1016/j.bmc.2006.06.040

Reference yield:

: 681128-21-2
tert-butyl (3R,5R,6S)-3-(2-methylprop-2-enyl)-2-oxo-5,6-diphenylmorpholine-4-carboxylate

: 681128-24-5
[(R)-2-[(S)-2-(5-Chloro-2-tetrazol-1-yl-benzylcarbamoyl)-4,4-difluoro-pyrrolidin-1-yl]-1-(1-methyl-cyclopropylmethyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: KOH / H₂O; diethyl ether / 0.08 h / 0 °C

1.2: 86 percent / Pd(OAc)2 / tetrahydrofuran; diethyl ether / 0 °C

2.1: 86 percent / LiNH₂ / ethanol; tetrahydrofuran / 0.17 h / -78 °C

3.1: 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide HCl; 1-hydroxy-7-aza-1H-benzotriazole; Huenig's base / dimethylformamide / 18 h / 20 °C / pH 6 - 8

With potassium hydroxide; 1-hydroxy-7-aza-benzotriazole; lithium amide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; diethyl ether; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.06.040

Reference yield:

: 681128-22-3
tert-butyl (3R,5R,6S)-3-[(1-methylcyclopropyl)methyl]-2-oxo-5,6-diphenylmorpholine-4-carboxylate

: 681128-24-5
[(R)-2-[(S)-2-(5-Chloro-2-tetrazol-1-yl-benzylcarbamoyl)-4,4-difluoro-pyrrolidin-1-yl]-1-(1-methyl-cyclopropylmethyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / LiNH₂ / ethanol; tetrahydrofuran / 0.17 h / -78 °C

2: 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide HCl; 1-hydroxy-7-aza-1H-benzotriazole; Huenig's base / dimethylformamide / 18 h / 20 °C / pH 6 - 8

With 1-hydroxy-7-aza-benzotriazole; lithium amide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.06.040