3-(2-phenoxyquinolin-3-yl)-1-(4-chlorophenyl)-2-propen-1-one

Base Information

• Chemical Name: 3-(2-phenoxyquinolin-3-yl)-1-(4-chlorophenyl)-2-propen-1-one
• CAS No.: 1345719-13-2
• Molecular Formula: C₂₄H₁₆ClNO₂
• Molecular Weight: 385.85
• Mol file: 1345719-13-2.mol

Synonyms:3-(2-phenoxyquinolin-3-yl)-1-(4-chlorophenyl)-2-propen-1-one

Chemical Property of 3-(2-phenoxyquinolin-3-yl)-1-(4-chlorophenyl)-2-propen-1-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(2-phenoxyquinolin-3-yl)-1-(4-chlorophenyl)-2-propen-1-one

There total 3 articles about 3-(2-phenoxyquinolin-3-yl)-1-(4-chlorophenyl)-2-propen-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2-phenoxyquinoline-3-carbaldehyde (1039857-01-6) + para-chloroacetophenone (99-91-2) → 3-(2-phenoxyquinolin-3-yl)-1-(4-chlorophenyl)-2-propen-1-one (1345719-13-2)

Guidance literature:

With potassium hydroxide; In water; at 0 ℃; for 2h; Cooling with ice;

DOI:10.1080/10426507.2011.621002

Reference yield:

2-chloro-3-quinoline carboxaldehyde (73568-25-9) → 3-(2-phenoxyquinolin-3-yl)-1-(4-chlorophenyl)-2-propen-1-one (1345719-13-2)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydroxide / dimethyl sulfoxide / 6 h / 85 - 90 °C

2: potassium hydroxide / water / 2 h / 0 °C / Cooling with ice

With potassium hydroxide; In water; dimethyl sulfoxide; 2: Claisen Schmidt condensation;

DOI:10.1080/10426507.2011.621002

Reference yield:

phenol (108-95-2,27073-41-2) → 3-(2-phenoxyquinolin-3-yl)-1-(4-chlorophenyl)-2-propen-1-one (1345719-13-2)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydroxide / dimethyl sulfoxide / 6 h / 85 - 90 °C

2: potassium hydroxide / water / 2 h / 0 °C / Cooling with ice

With potassium hydroxide; In water; dimethyl sulfoxide; 2: Claisen Schmidt condensation;

DOI:10.1080/10426507.2011.621002

upstream raw materials:

2-phenoxyquinoline-3-carbaldehyde

para-chloroacetophenone

2-chloro-3-quinoline carboxaldehyde

phenol

Downstream raw materials:

C₃₃H₂₃ClN₄OS

C₃₃H₂₂Cl₂N₄OS

C₃₄H₂₅ClN₄O₂S

C₂₅H₁₉ClN₄OS