N-[{(4S,5R)-5-[(diphenyl)(sulfanyl)methyl]-2,2-dimethyl-1,3-dioxolan-4-yl}(diphenyl)methyl]-1,1,1-trifluoromethanesulfonamide

Base Information

Chemical Name:N-[{(4S,5R)-5-[(diphenyl)(sulfanyl)methyl]-2,2-dimethyl-1,3-dioxolan-4-yl}(diphenyl)methyl]-1,1,1-trifluoromethanesulfonamide
CAS No.:1400792-80-4
Molecular Formula:C₃₂H₃₀F₃NO₄S₂
Molecular Weight:613.722
Hs Code.:

Synonyms:N-[{(4S,5R)-5-[(diphenyl)(sulfanyl)methyl]-2,2-dimethyl-1,3-dioxolan-4-yl}(diphenyl)methyl]-1,1,1-trifluoromethanesulfonamide

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Chemical Property of N-[{(4S,5R)-5-[(diphenyl)(sulfanyl)methyl]-2,2-dimethyl-1,3-dioxolan-4-yl}(diphenyl)methyl]-1,1,1-trifluoromethanesulfonamide

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Technology Process of N-[{(4S,5R)-5-[(diphenyl)(sulfanyl)methyl]-2,2-dimethyl-1,3-dioxolan-4-yl}(diphenyl)methyl]-1,1,1-trifluoromethanesulfonamide

There total 4 articles about N-[{(4S,5R)-5-[(diphenyl)(sulfanyl)methyl]-2,2-dimethyl-1,3-dioxolan-4-yl}(diphenyl)methyl]-1,1,1-trifluoromethanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1400792-74-6
N-({(4S,5R)-5-[(chloro)(diphenyl)methyl]-2,2-dimethyl-1,3-dioxolan-4-yl}diphenylmethyl)-1,1,1-trifluoromethanesulfonamide

: 1400792-80-4
N-[{(4S,5R)-5-[(diphenyl)(sulfanyl)methyl]-2,2-dimethyl-1,3-dioxolan-4-yl}(diphenyl)methyl]-1,1,1-trifluoromethanesulfonamide

Guidance literature:: N-({(4S,5R)-5-[(chloro)(diphenyl)methyl]-2,2-dimethyl-1,3-dioxolan-4-yl}diphenylmethyl)-1,1,1-trifluoromethanesulfonamide; With thiourea; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 72h;

With sodium hydroxide; In diethyl ether; dichloromethane; N,N-dimethyl-formamide; for 1h;
DOI:10.1002/hlca.201200146

Reference yield:

: 193892-87-4
N-{[(4S,5R)-5-(Diphenyl-trimethylsilanyloxy-methyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-diphenyl-methyl}-C,C,C-trifluoro-methanesulfonamide

: 1400792-80-4
N-[{(4S,5R)-5-[(diphenyl)(sulfanyl)methyl]-2,2-dimethyl-1,3-dioxolan-4-yl}(diphenyl)methyl]-1,1,1-trifluoromethanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

2.1: thionyl chloride; lithium chloride / tetrahydrofuran / 6 h / Reflux

3.1: thiourea / dichloromethane; N,N-dimethyl-formamide / 72 h / 20 °C

3.2: 1 h

With thionyl chloride; tetrabutyl ammonium fluoride; thiourea; lithium chloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/hlca.201200146

Reference yield:

: C,C,C-Trifluoro-N-{[(4S,5R)-5-(hydroxy-diphenyl-methyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-diphenyl-methyl}-methanesulfonamide

: 1400792-80-4
N-[{(4S,5R)-5-[(diphenyl)(sulfanyl)methyl]-2,2-dimethyl-1,3-dioxolan-4-yl}(diphenyl)methyl]-1,1,1-trifluoromethanesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: thionyl chloride; lithium chloride / tetrahydrofuran / 6 h / Reflux

2.1: thiourea / dichloromethane; N,N-dimethyl-formamide / 72 h / 20 °C

2.2: 1 h

With thionyl chloride; thiourea; lithium chloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/hlca.201200146