(S)-2-Benzyloxycarbonylamino-5-[(R)-1-((1R,2R)-1-benzyloxycarbonyl-2-methoxy-propylcarbamoyl)-2-benzylsulfanyl-ethylcarbamoyl]-pentanoic acid benzyl ester

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Chemical Name:(S)-2-Benzyloxycarbonylamino-5-[(R)-1-((1R,2R)-1-benzyloxycarbonyl-2-methoxy-propylcarbamoyl)-2-benzylsulfanyl-ethylcarbamoyl]-pentanoic acid benzyl ester
CAS No.:104181-93-3
Molecular Formula:C₄₃H₄₉N₃O₉S
Molecular Weight:783.943
Hs Code.:

(S)-2-Benzyloxycarbonylamino-5-[(R)-1-((1R,2R)-1-benzyloxycarbonyl-2-methoxy-propylcarbamoyl)-2-benzylsulfanyl-ethylcarbamoyl]-pentanoic acid benzyl ester

Synonyms:(S)-2-Benzyloxycarbonylamino-5-[(R)-1-((1R,2R)-1-benzyloxycarbonyl-2-methoxy-propylcarbamoyl)-2-benzylsulfanyl-ethylcarbamoyl]-pentanoic acid benzyl ester

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Chemical Property of (S)-2-Benzyloxycarbonylamino-5-[(R)-1-((1R,2R)-1-benzyloxycarbonyl-2-methoxy-propylcarbamoyl)-2-benzylsulfanyl-ethylcarbamoyl]-pentanoic acid benzyl ester

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Technology Process of (S)-2-Benzyloxycarbonylamino-5-[(R)-1-((1R,2R)-1-benzyloxycarbonyl-2-methoxy-propylcarbamoyl)-2-benzylsulfanyl-ethylcarbamoyl]-pentanoic acid benzyl ester

There total 5 articles about (S)-2-Benzyloxycarbonylamino-5-[(R)-1-((1R,2R)-1-benzyloxycarbonyl-2-methoxy-propylcarbamoyl)-2-benzylsulfanyl-ethylcarbamoyl]-pentanoic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 79761-10-7
[(N-benzyloxycarbonyl)-(α-benzyl)-δ-(L-α-aminoadipoyl)]-S-benzyl-L-cysteine

: 208929-07-1
O-methyl-D-threonine benzyl ester

: 104181-93-3
(S)-2-Benzyloxycarbonylamino-5-[(R)-1-((1R,2R)-1-benzyloxycarbonyl-2-methoxy-propylcarbamoyl)-2-benzylsulfanyl-ethylcarbamoyl]-pentanoic acid benzyl ester

Guidance literature:: With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; In dichloromethane; Ambient temperature;
DOI:10.1016/S0040-4020(98)00280-4

Reference yield:

: 82679-58-1
(2R,3S)-threonine benzyl ester

: 104181-93-3
(S)-2-Benzyloxycarbonylamino-5-[(R)-1-((1R,2R)-1-benzyloxycarbonyl-2-methoxy-propylcarbamoyl)-2-benzylsulfanyl-ethylcarbamoyl]-pentanoic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N / tetrahydrofuran

2: 486 mg / BF₃*Et₂O / CH₂Cl₂ / 0.5 h

3: 68 percent / 45percent HBr, AcOH / CH₂Cl₂ / 0.5 h / Ambient temperature

4: 77 percent / 2-ethoxy-N-ethoxycarbonyl-1,2-dihydroquinoline / CH₂Cl₂ / Ambient temperature

With boron trifluoride diethyl etherate; hydrogen bromide; acetic acid; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0040-4020(98)00280-4

Reference yield:

: 85995-50-2
N-Z-D-threonine benzyl ester

: 104181-93-3
(S)-2-Benzyloxycarbonylamino-5-[(R)-1-((1R,2R)-1-benzyloxycarbonyl-2-methoxy-propylcarbamoyl)-2-benzylsulfanyl-ethylcarbamoyl]-pentanoic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 486 mg / BF₃*Et₂O / CH₂Cl₂ / 0.5 h

2: 68 percent / 45percent HBr, AcOH / CH₂Cl₂ / 0.5 h / Ambient temperature

3: 77 percent / 2-ethoxy-N-ethoxycarbonyl-1,2-dihydroquinoline / CH₂Cl₂ / Ambient temperature

With boron trifluoride diethyl etherate; hydrogen bromide; acetic acid; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; In dichloromethane;
DOI:10.1016/S0040-4020(98)00280-4