1H-Benzimidazole,2-(hydrazinomethyl)-(9CI)

Base Information

• Chemical Name: 1H-Benzimidazole,2-(hydrazinomethyl)-(9CI)
• CAS No.: 99303-41-0
• Molecular Formula: C8H10 N4
• Molecular Weight: 162.194
• Mol file: 99303-41-0.mol

Synonyms:1H-Benzimidazole,2-(hydrazinomethyl)- (9CI); Benzimidazole, 2-hydrazinomethyl- (6CI);2-Hydrazinomethylbenzimidazole

Chemical Property of 1H-Benzimidazole,2-(hydrazinomethyl)-(9CI)

Chemical Property:

• Boiling Point: 476.5±28.0 °C(Predicted)
• PKA: 11.72±0.10(Predicted)
• PSA: 66.73000
• Density: 1.309±0.06 g/cm3(Predicted)
• LogP: 1.61740

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Benzimidazole,2-(hydrazinomethyl)-(9CI)

There total 5 articles about 1H-Benzimidazole,2-(hydrazinomethyl)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(1H-benzimidazol-2-yl)methanethiol (4344-85-8) → 2-(hydrazinylmethyl)-1H-benzo[d]imidazole (99303-41-0)

Guidance literature:

With hydrazine hydrate monohydrate; In ethanol; for 20h; Reflux;

DOI:10.1016/j.ejphar.2020.173747

Reference yield: 75.0%

2-chloromethyl-1H-benzimidazole (4857-04-9) → 2-(hydrazinylmethyl)-1H-benzo[d]imidazole (99303-41-0)

Guidance literature:

With hydrazine hydrate; for 0.75h; Reflux;

DOI:10.1016/j.ejmech.2012.03.028

Reference yield: 62.0%

2-(bromomethyl)-1,3-benzimidazole (30770-24-2) → 2-(hydrazinylmethyl)-1H-benzo[d]imidazole (99303-41-0)

Guidance literature:

With hydrazine hydrate; for 2h; Reflux;

DOI:10.1002/jhet.3522

upstream raw materials:

2-(bromomethyl)-1,3-benzimidazole

2-(Hydroxymethyl)benzimidazole

2-chloromethyl-1H-benzimidazole

1,2-diamino-benzene

Downstream raw materials:

1-[(2-trifluoromethyl)phenyl]-1,2,3,4-tetrahydro[1,2,4]triazino[4,5-a]benzimidazole

1-(4-fluorophenyl)-1,2,3,4-tetrahydro[1,2,4]triazino[4,5-a]benzimidazole

1-(4-chlorophenyl)-1,2,3,4-tetrahydro[1,2,4]triazino[4,5-a]benzimidazole

1-(2-chlorophenyl)-1,2,3,4-tetrahydro[1,2,4]triazino[4,5-a]benzimidazole

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