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30770-24-2

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30770-24-2 Usage

General Description

2-(bromomethyl)-1H-benzimidazole is a chemical compound with the molecular formula C8H7BrN2. It is a benzimidazole derivative with a bromomethyl group attached to the benzene ring. 2-(bromomethyl)-1H-benzimidazole is commonly used in organic synthesis and medicinal chemistry as a versatile building block for the preparation of various biologically active molecules. It is also used as a reagent in the synthesis of pharmaceuticals and agrochemicals. Additionally, 2-(bromomethyl)-1H-benzimidazole has been studied for its potential antiparasitic and antimicrobial properties, making it a valuable compound for drug discovery and development.

Check Digit Verification of cas no

The CAS Registry Mumber 30770-24-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,0,7,7 and 0 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 30770-24:
(7*3)+(6*0)+(5*7)+(4*7)+(3*0)+(2*2)+(1*4)=92
92 % 10 = 2
So 30770-24-2 is a valid CAS Registry Number.

30770-24-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-(bromomethyl)-1H-benzimidazole

1.2 Other means of identification

Product number -
Other names 2-bromomethyl-1H-benzoimidazole

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:30770-24-2 SDS

30770-24-2Relevant articles and documents

Synthesis, characterization and antibacterial evaluation of some novel derivatives of 2-bromomethyl-benzimidazole

Ahmadi, Abbas

, p. 451 - 456 (2014)

In the present study, synthesis, and biological evaluation of some novel derivatives of 2-bromomethyl-benzimidazole were investigated. The structures of the new synthesized compounds were characterized by IR, 1H-NMR, 13C-NMR, mass spectrometry and elemental analysis and screened for antimicrobial activity against two Gram-positive strains (Staphylococcus aureus and Bacillus subtilis) and two Gram-negative strains (Escherichia coli and Pseudomonas aeruginosa). Results indicate that new compounds showed moderate to good activity when compared with standard antibiotic Ciprofloxacin and Streptomycin.

Straightforward synthesis of photoactive chalcogen functionalized benzimidazo[1,2-a] quinolines

Da Silva, Rodrigo Borges,Lange Coelho, Felipe,Rodembusch, Fabiano Severo,Schwab, Ricardo Samuel,Schneider, Juliana Maria Forain Miolo,Da Silveira Rampon, Daniel,Schneider, Paulo Henrique

supporting information, p. 11596 - 11603 (2019/07/31)

A series of new organochalcogen derivatives of benzimidazo[1,2-a]quinolines were synthesized in moderate to excellent yields and in short reaction times from chalcogen benzimidazoles, in a straightforward synthetic procedure, through transition-metal-free cascade reactions involving a sequential intermolecular aromatic nucleophilic substitution (SNAr), followed by an intramolecular Knoevenagel condensation. Both the sulfur and selenium derivatives presented similar photophysical properties, with absorption maxima located in the UV region (~355 nm) related to spin and symmetry allowed electronic p-p? transitions, and fluorescence emission located in the violet-blue region (~440 nm) with a relatively large Stokes shift (~90 nm). The fluorescence quantum yields were slightly influenced by the chalcogen, with the sulfur derivatives presenting higher values than the selenium analogues, probably due to the intersystem crossing allowed by the selenium atom. Moreover no clear evidence for charge transfer in either compound in the ground and excited states was observed.

Cucurbit[7]uril-improved recognition by a fluorescent sensor for cadmium and zinc cations

Geng, Qing-Xia,Cong, Hang,Tao, Zhu,Lindoy, Leonard F.,Wei, Gang

, p. 784 - 791 (2016/10/20)

The host–guest interaction of cucurbit[7]uril (Q[7]) with the new fluorescent sensor guest molecule (BIBPAH+), formed by alkylation of the secondary amine site in N,N-bis(2-pyridylmethyl)amine with 2-(bromomethyl)benzimidazole, was investigated by fluorescence and 1H NMR spectroscopy. The results indicate the formation of an inclusion complex in a 1:1 ratio with an association constant of Ka?=?(2.9?±?0.7) × 105 L ? mol?1. There is minimal difference in the fluorescence intensities upon the introduction of each of Mn2+, Ni2+, Co2+, Cr3+, Ho3+ and Lu3+. However, the emission was slightly quenched on the addition of Cu2+ or Fe3+ whether Q[7] is present or not. Further investigation showed that encapsulation of BIBPAH+ in Q[7] improves Cd2+ and Zn2+ recognition by enhancing the fluorescence intensity, leading to an improvement in the limits of detection. In contrast, comparative parallel experiments in which Cu2+, Mn2+, Ni2+, Co2+, Fe3+, Cr3+, Ho3+ or Lu3+ were substituted for Zn2+ or Cd2+ resulted in minimal changes in the fluorescence that occurs for the corresponding metal-free system. The natures of the encapsulated Zn2+ and Cd2+ complexes have been investigated using fluorescence and 1H NMR spectroscopy as well as by quantum chemistry.

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