2-(1,4-bis-(4-fluorophenyl)-1H-imidazol-2-yl)-1-(4-(4-methoxypyridin-2-yl)piperazin-1-yl)ethanone

Base Information

Chemical Name:2-(1,4-bis-(4-fluorophenyl)-1H-imidazol-2-yl)-1-(4-(4-methoxypyridin-2-yl)piperazin-1-yl)ethanone
CAS No.:1443769-41-2
Molecular Formula:C₂₇H₂₅F₂N₅O₂
Molecular Weight:489.525
Hs Code.:

Synonyms:2-(1,4-bis-(4-fluorophenyl)-1H-imidazol-2-yl)-1-(4-(4-methoxypyridin-2-yl)piperazin-1-yl)ethanone

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Chemical Property of 2-(1,4-bis-(4-fluorophenyl)-1H-imidazol-2-yl)-1-(4-(4-methoxypyridin-2-yl)piperazin-1-yl)ethanone

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Technology Process of 2-(1,4-bis-(4-fluorophenyl)-1H-imidazol-2-yl)-1-(4-(4-methoxypyridin-2-yl)piperazin-1-yl)ethanone

There total 5 articles about 2-(1,4-bis-(4-fluorophenyl)-1H-imidazol-2-yl)-1-(4-(4-methoxypyridin-2-yl)piperazin-1-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1443435-98-0
(1,4-bis-(4-fluoro-phenyl)-1H-imidazol-2-yl)-acetic acid ethyl ester

: 444666-41-5
1-(4-methoxy-pyridin-2-yl)-piperazine

: 1443769-41-2
2-(1,4-bis-(4-fluorophenyl)-1H-imidazol-2-yl)-1-(4-(4-methoxypyridin-2-yl)piperazin-1-yl)ethanone

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 180 ℃; for 0.833333h; Microwave irradiation;

Reference yield:

: 146537-23-7
1-(4-fluoro-phenyl)-2-(4-fluoro-phenylamino)-ethanone

: 1443769-41-2
2-(1,4-bis-(4-fluorophenyl)-1H-imidazol-2-yl)-1-(4-(4-methoxypyridin-2-yl)piperazin-1-yl)ethanone

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 2 h / 20 °C

2: acetic acid; ammonium acetate / 4 h / Reflux

3: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 0.83 h / 180 °C / Microwave irradiation

With ammonium acetate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; dichloromethane;

Reference yield:

: 371-40-4
4-fluoroaniline

: 1443769-41-2
2-(1,4-bis-(4-fluorophenyl)-1H-imidazol-2-yl)-1-(4-(4-methoxypyridin-2-yl)piperazin-1-yl)ethanone

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran / 7 h / 20 - 40 °C

2: triethylamine / dichloromethane / 2 h / 20 °C

3: acetic acid; ammonium acetate / 4 h / Reflux

4: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 0.83 h / 180 °C / Microwave irradiation

With ammonium acetate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane;