ethyl 16-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)hexadecanoate

Base Information

Chemical Name:ethyl 16-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)hexadecanoate
CAS No.:1611446-67-3
Molecular Formula:C₂₆H₄₀ClF₃N₂O₃
Molecular Weight:521.063
Hs Code.:

Synonyms:ethyl 16-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)hexadecanoate

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Chemical Property of ethyl 16-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)hexadecanoate

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Technology Process of ethyl 16-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)hexadecanoate

There total 4 articles about ethyl 16-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)hexadecanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: ethyl 16-aminohexadecanoate

: 327-78-6
4-chloro-3-(trifluoromethyl)phenyl isocyanate

: 1611446-67-3
ethyl 16-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)hexadecanoate

Guidance literature:: In tetrahydrofuran; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.7b00701

Reference yield:

: 506-13-8
16-hydroxyhexadecanoic acid

: 1611446-67-3
ethyl 16-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)hexadecanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetyl chloride / 4 h / 20 °C

2.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0.5 h / 0 °C

2.2: 4.5 h / 0 - 20 °C

3.1: triphenylphosphine / tetrahydrofuran / 16 h / 20 °C

3.2: 16 h

4.1: tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

With di-isopropyl azodicarboxylate; acetyl chloride; triphenylphosphine; In tetrahydrofuran;

Reference yield:

: 85258-69-1
ethyl 16-hydroxyhexadecanoate

: 1611446-67-3
ethyl 16-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)hexadecanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0.5 h / 0 °C

1.2: 4.5 h / 0 - 20 °C

2.1: triphenylphosphine / tetrahydrofuran / 16 h / 20 °C

2.2: 16 h

3.1: tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran;