16-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-hexadecanoic acid

Base Information

Chemical Name:16-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-hexadecanoic acid
CAS No.:1611446-66-2
Molecular Formula:C₂₄H₃₆ClF₃N₂O₃
Molecular Weight:493.01
Hs Code.:

Synonyms:16-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-hexadecanoic acid

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Chemical Property of 16-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-hexadecanoic acid

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Technology Process of 16-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-hexadecanoic acid

There total 6 articles about 16-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-hexadecanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1611446-67-3
ethyl 16-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)hexadecanoate

: 1611446-66-2
16-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-hexadecanoic acid

Guidance literature:: With sodium hydroxide; In ethanol; water; at 40 ℃; for 3h;
DOI:10.1021/acs.jmedchem.7b00701

Reference yield:

: 506-13-8
16-hydroxyhexadecanoic acid

: 1611446-66-2
16-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-hexadecanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetyl chloride / 4 h / 20 °C

2.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0.5 h / 0 °C

2.2: 4.5 h / 0 - 20 °C

3.1: triphenylphosphine / tetrahydrofuran / 16 h / 20 °C

3.2: 16 h

4.1: tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

5.1: ethanol; sodium hydroxide / 3 h / 40 °C

With ethanol; di-isopropyl azodicarboxylate; acetyl chloride; triphenylphosphine; sodium hydroxide; In tetrahydrofuran;

Reference yield:

: ethyl 16-azidohexadecanoate

: 1611446-66-2
16-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-hexadecanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: triphenylphosphine / tetrahydrofuran / 16 h / 20 °C

1.2: 16 h

2.1: tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

3.1: ethanol; sodium hydroxide / 3 h / 40 °C

With ethanol; triphenylphosphine; sodium hydroxide; In tetrahydrofuran;