trans-(7R,8R)-7,8-dibenzoyloxy-7,8,9,10-tetrahydrobenzopyrene

• Chemical Name: trans-(7R,8R)-7,8-dibenzoyloxy-7,8,9,10-tetrahydrobenzopyrene
• Molecular Formula: C₃₄H₂₄O₄
• Molecular Weight: 496.562
• Mol file: 169437-81-4.mol

Synonyms:trans-(7R,8R)-7,8-dibenzoyloxy-7,8,9,10-tetrahydrobenzopyrene

Chemical Property of trans-(7R,8R)-7,8-dibenzoyloxy-7,8,9,10-tetrahydrobenzo

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of trans-(7R,8R)-7,8-dibenzoyloxy-7,8,9,10-tetrahydrobenzo

There total 5 articles about trans-(7R,8R)-7,8-dibenzoyloxy-7,8,9,10-tetrahydrobenzopyrene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

9,10-dihydro benzopyrene (17573-15-8) → trans-(7R,8R)-7,8-dibenzoyloxy-7,8,9,10-tetrahydrobenzopyrene (169437-81-4)

Guidance literature:

Multi-step reaction with 3 steps

1: I₂

2: 1.) NaOMe

3: 1.) NaOMe; 2.) pyridine

With pyridine; iodine; sodium methylate;

DOI:10.1016/S0040-4039(00)76952-8

Reference yield:

7,8-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (36504-67-3,82079-65-0) → trans-(7R,8R)-7,8-dibenzoyloxy-7,8,9,10-tetrahydrobenzopyrene (169437-81-4)

Guidance literature:

Multi-step reaction with 2 steps

1: AlMe₃ / toluene; diethyl ether / 1 h / Ambient temperature

2: 1.) NaOMe; 2.) pyridine

With pyridine; trimethylaluminum; sodium methylate; In diethyl ether; toluene;

DOI:10.1016/S0040-4039(00)76952-8

Reference yield:

benzoic acid anhydride (93-97-0) + 7,8,9,10-Tetrahydro-benzo[def]chrysene-7,8-diol → trans-(7S,8S)-7,8-dibenzoyloxy-7,8,9,10-tetrahydrobenzopyrene (63268-35-9) + trans-(7R,8R)-7,8-dibenzoyloxy-7,8,9,10-tetrahydrobenzopyrene (169437-81-4)

Guidance literature:

With dmap; triethylamine; In dichloromethane; for 2h; Yield given. Yields of byproduct given; Ambient temperature;

DOI:10.1039/c39950001699

upstream raw materials:

benzoyl chloride

(S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (7R,8R)-8-hydroxy-7,8,9,10-tetrahydro-benzo[def]chrysen-7-yl ester

benzoic acid anhydride

9,10-dihydro benzopyrene

Downstream raw materials:

(-)-7R-trans-Benzopyrene-7,8-dihydrodiol

(-)-(7R,8S,9S,10R)-7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene

7,8-bis-benzoyloxy-7,8-dihydro benzo[a]pyrene