(R)-4-(Isoquinoline-5-sulfonyl)-3-methyl-piperazine-1-carboxylic acid tert-butyl ester dihydrochloride

Base Information

• Chemical Name: (R)-4-(Isoquinoline-5-sulfonyl)-3-methyl-piperazine-1-carboxylic acid tert-butyl ester dihydrochloride
• CAS No.: 936233-10-2
• Molecular Formula: C₁₄H₁₇N₃O₂S*2ClH
• Molecular Weight: 364.296
• Mol file: 936233-10-2.mol

Synonyms:(R)-4-(Isoquinoline-5-sulfonyl)-3-methyl-piperazine-1-carboxylic acid tert-butyl ester dihydrochloride

Chemical Property of (R)-4-(Isoquinoline-5-sulfonyl)-3-methyl-piperazine-1-carboxylic acid tert-butyl ester dihydrochloride

Chemical Property:

• PSA: 88.19000
• LogP: 5.42530

Purity/Quality:

97% ^*data from raw suppliers

(R)-4-(ISOQUINOLINE-5-SULFONYL)-3-METHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER DIHYDROCHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-4-(Isoquinoline-5-sulfonyl)-3-methyl-piperazine-1-carboxylic acid tert-butyl ester dihydrochloride

There total 6 articles about (R)-4-(Isoquinoline-5-sulfonyl)-3-methyl-piperazine-1-carboxylic acid tert-butyl ester dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.3%

tert-butyl (3R)-4-(isoquinoline-5-sulfonyl)-3-methylpiperazine-1-carboxylate → 5-{[(2R)-2-methylpiperazin-4-ium-1-yl]sulfonyl}isoquinolin-2-ium dichloride (936233-08-8,936233-10-2)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; chloroform; at 20 ℃; for 18h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.8b00105

Reference yield: 90.5%

tert-butyl (3S)-4-(isoquinoline-5-sulfonyl)-3-methylpiperazine-1-carboxylate → 5-{[(2S)-2-methylpiperazin-4-ium-1-yl]sulfonyl}isoquinolin-2-ium dichloride (936233-08-8,936233-10-2)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; chloroform; at 20 ℃; for 18h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.8b00105

Reference yield:

→ 1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride (108930-17-2,936233-08-8,936233-10-2)

Guidance literature:

upstream raw materials:

isoquinoline-5-sulfonyl chloride hydrochloride

isoquinoline-5-sulfonic acid

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