Technology Process of 2-(2’,4’-dihydroxyphenyl)-5,6-methylenedioxybenzofuran
There total 14 articles about 2-(2’,4’-dihydroxyphenyl)-5,6-methylenedioxybenzofuran which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium on activated charcoal;
In
ethyl acetate;
at 20 ℃;
for 1h;
DOI:10.1021/jo00094a002
- Guidance literature:
-
With
potassium fluoride on basic alumina;
In
N,N-dimethyl-formamide;
at 120 ℃;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 93 percent / K2CO3 / acetone / 15 h / Heating
2: 82 percent / N,N-dimethylaniline / 2.5 h / 190 °C
3: 85 percent / KOH / butan-1-ol / 2 h / Heating
4: 70 percent / NaOH / n-Bu4NHSO4 / dioxane / 1.) r.t., 17 h, 2.) 60 deg C, 2 h
5: 72 percent / TiCl4, Zn, TMEDA / PbCl2 / tetrahydrofuran / 20 h / 25 °C
6: 85 percent / Mo(CHCMe2Ph)(NAr)(OCMe(CF3)2)2 (Ar = 2,6-(i-Pr)2C6H3) / benzene / 2 h / 60 °C
7: 96 percent / H2 / 10percent Pd/C / ethyl acetate / 1 h / 20 °C
With
potassium hydroxide; sodium hydroxide; N,N,N,N,-tetramethylethylenediamine; hydrogen; titanium tetrachloride; potassium carbonate; N,N-dimethyl-aniline; zinc;
palladium on activated charcoal; Mo(CHCMe2Ph)2; tetra(n-butyl)ammonium hydrogensulfate; lead(II) chloride;
In
tetrahydrofuran; 1,4-dioxane; ethyl acetate; acetone; butan-1-ol; benzene;
DOI:10.1021/jo00094a002
