4720-68-7

Basic information

• Product Name: 2-Hydroxy-4,5-methylenedioxybenzaldehyde
• Synonyms: 2-Hydroxy-4,5-methylenedioxybenzaldehyde;6-hydroxy-1,3-benzodioxole-5-carbaldehyde;6-Hydroxy-2H-1,3-benzodioxole-5-carbaldehyde
• CAS NO: 4720-68-7
• Molecular Formula: C₈H₆O₄
• Molecular Weight: 166.13
• Mol File: 4720-68-7.mol
• Article Data: 38

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 2-Hydroxy-4,5-methylenedioxybenzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Hydroxy-4,5-methylenedioxybenzaldehyde(4720-68-7)
• EPA Substance Registry System: 2-Hydroxy-4,5-methylenedioxybenzaldehyde(4720-68-7)

Safety Data

• Hazardous Substances Data: 4720-68-7(Hazardous Substances Data)

Usage

General Description

2-Hydroxy-4,5-methylenedioxybenzaldehyde is a chemical compound that consists of a benzene ring with a methylenedioxy group and a hydroxyl group attached to it, along with an aldehyde functional group. It is often used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. 2-Hydroxy-4,5-methylenedioxybenzaldehyde has been studied for its potential antioxidant and anti-inflammatory properties, making it of interest for potential therapeutic applications. However, it is important to note that this compound should be handled and used with caution, as it may have potential health hazards if not handled properly. Overall, 2-Hydroxy-4,5-methylenedioxybenzaldehyde has a range of potential uses and applications in various industries.

Upstream product

• 67-56-1 methanol 
• 34587-60-5 2-(trans-1-propenyl)-4,5-(methylenedioxy)phenol 
• 533-31-3 Sesamol 
• 100-97-0 hexamethylenetetramine 
• 4885-02-3 Dichloromethyl methyl ether 
• 557-21-1 zinc(II) cyanide 
• 23126-68-3 6-amino-benzo[1,3]dioxole-5-carbaldehyde 
• 712-97-0 6-nitro-1,3-benzodioxole-5-carbaldehyde 
• 120-57-0 piperonal 
• 68-12-2 N,N-dimethyl-formamide 
• 19202-23-4 5-hydroxy-6-(2-propenyl)-1,3-benzodioxole 
• 19202-22-3 O-allyl-sesamol 
• 326-58-9 acetic acid benzo[1,3]dioxol-5-yl ester 
• 122-51-0 orthoformic acid triethyl ester 

Downstream Products

• 96823-04-0 7-Phenoxy-[1,3]dioxolo[4,5-g]chromen-6-one 
• 494-56-4 ayapin 
• 85593-78-8 2-formyl-4,5-methylenedioxyphenyl 2',4'-dibenzyloxybenzoate 
• 19202-31-4 6-(benzyloxy)benzo[d][1,3]dioxole-5-carbaldehyde 
• 949585-62-0 (E)-3-(6-hydroxybenzo(1,3)dioxo-5-yl)-2-methyl-acrylic acid ethyl ester 
• 949585-64-2 (E)-3-(6-hydroxybenzo(1,3)dioxo-5-yl)-acrylic acid ethyl ester 
• 21505-20-4 1,2-dihydroxy-4,5-methylenedioxybenzene 
• 1192469-71-8 2-(t-butyldimethylsilanyloxy)-4,5-methylenedioxybenzaldehyde 
• 1357912-36-7 C₁₁H₁₁NO₄S 
• 1427216-08-7 3-((2-iodo-5-methoxyphenoxy)methyl)-5,6-methylene-dioxybenzofuran 
• 3187-53-9 flemichapparin B 
• 1427216-04-3 ethyl 5,6-methylenedioxybenzofuran-3-carboxylate 
• 89967-40-8 6-chloro-acetamidopiperonal 

Relevant articles and documents

Formal Asymmetric Catalytic Thiolation with a Bifunctional Catalyst at a Water-Oil Interface: Synthesis of Benzyl Thiols

The enantioselective conjugated addition of tritylthiol to in situ generated ortho-quinone methides (o-QMs) is catalyzed by an acid-base bifunctional squaramide organocatalyst. The transformation proceeds with high yield (up to 99%) and stereoselectivity (up to 97:3 e.r.) using water as solvent under mild conditions. The catalyst system provides a new strategy for the synthesis of optically active benzyl mercaptans. Control experiments suggested that o-QMs are generated by the tertiary amine moiety of the squaramide organocatalyst and that the water-oil biphase is crucial for achieving high reactivity and stereoselectivity.

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Phosphine-catalyzed sequential (2+3)/(2+4) annulation of γ-vinyl allenoates: Access to the synthesis of chromeno[4,3-: B] pyrroles

A phosphine-catalyzed cascade (2+3)/(2+4) cyclization reaction of γ-vinyl allenoates with aldimine esters has been developed to provide a series of chromeno[4,3-b]pyrrole derivatives that contain three contiguous stereogenic centers. The method gives a good yield, excellent chemoselectivity and diastereoselectivity under mild conditions.

An unexpected Pummerer rearrangement in the synthetic route to ethyl (2′-hydroxy-4′,5′-methylenedioxyphenyl)acetate: An alternative approach to 2,3-dimethylthio benzofurans

The synthesis of ethyl (2′-hydroxy-4′,5′-methylendioxophenyl)acetate, a fragment of the antihyperglycemic natural coumarin subcoriacin, is reported. We found an expeditious route to the title compound in five steps. Final metal catalyzed acid ethanolysis of the vinylic 1,1-methylthio methylsulfoxide derivative afforded the required aryl acetic ester, but in the absence of metal catalyst, an unexpected Pummerer rearrangement produced the 2,3-dimethylthiofuran derivative as the major product. This last result provides an alternative entry to 2,3-dimethlythiobenzofurans.