(2S,3R,4R,5S)-7-Benzyloxy-3,5-bis-(tert-butyl-dimethyl-silanyloxy)-1-((1R,5S,7S)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-2,4-dimethyl-heptan-1-one

Base Information

• Chemical Name: (2S,3R,4R,5S)-7-Benzyloxy-3,5-bis-(tert-butyl-dimethyl-silanyloxy)-1-((1R,5S,7S)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-2,4-dimethyl-heptan-1-one
• CAS No.: 899798-75-5
• Molecular Formula: C₃₈H₆₇NO₆SSi₂
• Molecular Weight: 722.19

Synonyms:(2S,3R,4R,5S)-7-Benzyloxy-3,5-bis-(tert-butyl-dimethyl-silanyloxy)-1-((1R,5S,7S)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-2,4-dimethyl-heptan-1-one

Chemical Property of (2S,3R,4R,5S)-7-Benzyloxy-3,5-bis-(tert-butyl-dimethyl-silanyloxy)-1-((1R,5S,7S)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-2,4-dimethyl-heptan-1-one

Chemical Property:

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Technology Process of (2S,3R,4R,5S)-7-Benzyloxy-3,5-bis-(tert-butyl-dimethyl-silanyloxy)-1-((1R,5S,7S)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-2,4-dimethyl-heptan-1-one

There total 5 articles about (2S,3R,4R,5S)-7-Benzyloxy-3,5-bis-(tert-butyl-dimethyl-silanyloxy)-1-((1R,5S,7S)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-2,4-dimethyl-heptan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2R,3S)-5-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-1-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]dec-4-yl)-2-methyl-pentan-1-one (899798-73-3) → (2S,3R,4R,5S)-7-Benzyloxy-3,5-bis-(tert-butyl-dimethyl-silanyloxy)-1-((1R,5S,7S)-10,10-dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]dec-4-yl)-2,4-dimethyl-heptan-1-one (899798-75-5)

Guidance literature:

Multi-step reaction with 3 steps

1: diisoibutylaluminum hydride / CH₂Cl₂; hexane / 1 h / -78 °C

2: CH₂Cl₂ / 16 h / -78 °C

3: 2,6-lutidine / CH₂Cl₂ / 1 h / Heating

With 2,6-dimethylpyridine; In hexane; dichloromethane; 2: Evans asymmetric aldolization;

DOI:10.1002/chem.200700342

Reference yield:

(2S,3R,4S,5S)-7-Benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-1-((1R,5S,7S)-10,10-dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]dec-4-yl)-3-hydroxy-2,4-dimethyl-heptan-1-one (899798-74-4) + t-butyldimethylsiyl triflate (69739-34-0) → (2S,3R,4R,5S)-7-Benzyloxy-3,5-bis-(tert-butyl-dimethyl-silanyloxy)-1-((1R,5S,7S)-10,10-dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]dec-4-yl)-2,4-dimethyl-heptan-1-one (899798-75-5)

Guidance literature:

With 2,6-dimethylpyridine; In dichloromethane; for 1h; Heating;

DOI:10.1021/ol060669w

Reference yield:

3-Benzyloxypropanal (19790-60-4) → (2S,3R,4R,5S)-7-Benzyloxy-3,5-bis-(tert-butyl-dimethyl-silanyloxy)-1-((1R,5S,7S)-10,10-dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]dec-4-yl)-2,4-dimethyl-heptan-1-one (899798-75-5)

Guidance literature:

Multi-step reaction with 5 steps

1.1: nBu₂BOTf; N,N-diisopropylethylamine / CH₂Cl₂ / 0.5 h / -5 °C

1.2: 95 percent / CH₂Cl₂ / 16 h / -78 °C

2.1: 88 percent / 2,6-lutidine / CH₂Cl₂ / 1 h / 20 °C

3.1: diisobutylaluminum hydride / CH₂Cl₂; hexane / 1 h / -78 °C

4.1: nBu₂BOTf; N,N-diisopropylethylamine / CH₂Cl₂ / 0.5 h / -5 °C

4.2: 3.98 g / CH₂Cl₂ / 16 h / -78 °C

5.1: 2,6-lutidine / CH₂Cl₂ / 1 h / Heating

With 2,6-dimethylpyridine; di-n-butylboryl trifluoromethanesulfonate; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; In hexane; dichloromethane;

DOI:10.1021/ol060669w

upstream raw materials:

(2S,3R,4S,5S)-7-Benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-1-((1R,5S,7S)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-3-hydroxy-2,4-dimethyl-heptan-1-one

t-butyldimethylsiyl triflate

(2R,3S)-5-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-1-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-2-methyl-pentan-1-one

(2S)-N-propionylcamphorsultam

Downstream raw materials:

(2S,3R,4R,5S)-7-Benzyloxy-3,5-bis-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethyl-heptanoic acid

(3S,4R,5R,6S)-8-Benzyloxy-4,6-bis-(tert-butyl-dimethyl-silanyloxy)-3,5-dimethyl-octan-2-one

[(3S,4R,5S,6R,7S)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-7-methoxy-4,6-dimethyl-octyloxymethyl]-benzene

(2S,3R,4R,5S)-7-Benzyloxy-3,5-bis-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethyl-heptanoic acid methoxy-methyl-amide

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