2-(8-carbomethoxymethyloxy-3-cyclohexylmethyl-2-cyclopropylindolizin-1-yl)glyoxylamide

Base Information

Chemical Name:2-(8-carbomethoxymethyloxy-3-cyclohexylmethyl-2-cyclopropylindolizin-1-yl)glyoxylamide
CAS No.:177557-96-9
Molecular Formula:C₂₃H₂₈N₂O₅
Molecular Weight:412.486
Hs Code.:

Synonyms:2-(8-carbomethoxymethyloxy-3-cyclohexylmethyl-2-cyclopropylindolizin-1-yl)glyoxylamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(8-carbomethoxymethyloxy-3-cyclohexylmethyl-2-cyclopropylindolizin-1-yl)glyoxylamide

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Technology Process of 2-(8-carbomethoxymethyloxy-3-cyclohexylmethyl-2-cyclopropylindolizin-1-yl)glyoxylamide

There total 6 articles about 2-(8-carbomethoxymethyloxy-3-cyclohexylmethyl-2-cyclopropylindolizin-1-yl)glyoxylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.7%

: 177557-96-9
2-(8-carbomethoxymethyloxy-3-cyclohexylmethyl-2-cyclopropylindolizin-1-yl)glyoxylamide

Guidance literature:

Reference yield:

: 1026906-74-0
(1-Chlorooxalyl-3-cyclohexylmethyl-2-cyclopropyl-indolizin-8-yloxy)-acetic acid methyl ester

: 177557-96-9
2-(8-carbomethoxymethyloxy-3-cyclohexylmethyl-2-cyclopropylindolizin-1-yl)glyoxylamide

Guidance literature:: With ammonium hydroxide; In tetrahydrofuran; for 1h; Yield given; Ambient temperature;
DOI:10.1021/jm960395q

Reference yield:

: 1121-25-1,55780-69-3
2-methyl-3-pyridinol

: 177557-96-9
2-(8-carbomethoxymethyloxy-3-cyclohexylmethyl-2-cyclopropylindolizin-1-yl)glyoxylamide

Guidance literature:: Multi-step reaction with 5 steps

1: 61 percent / NaH / dimethylformamide / Ambient temperature

2: 2.) 1,8-diazabicyclo<5.4.0>undec-7-ene / 1.) 95 deg C, 2 h, 2.) benzene, reflux, 1 h

3: 42.8 percent / benzene / 48 h / Ambient temperature

4: tetrahydrofuran / 1 h / 0 °C

5: aq. NH₄OH / tetrahydrofuran / 1 h / Ambient temperature

With ammonium hydroxide; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm960395q