(S)-4-{2-[Bis-(4-fluoro-phenyl)-pentafluorophenyl-methoxycarbonyl]-ethyl}-5-oxo-oxazolidine-3-carboxylic acid benzyl ester

Base Information

• Chemical Name: (S)-4-{2-[Bis-(4-fluoro-phenyl)-pentafluorophenyl-methoxycarbonyl]-ethyl}-5-oxo-oxazolidine-3-carboxylic acid benzyl ester
• CAS No.: 241823-95-0
• Molecular Formula: C₃₃H₂₂F₇NO₆
• Molecular Weight: 661.53
• Mol file: 241823-95-0.mol

Synonyms:(S)-4-{2-[Bis-(4-fluoro-phenyl)-pentafluorophenyl-methoxycarbonyl]-ethyl}-5-oxo-oxazolidine-3-carboxylic acid benzyl ester

Chemical Property of (S)-4-{2-[Bis-(4-fluoro-phenyl)-pentafluorophenyl-methoxycarbonyl]-ethyl}-5-oxo-oxazolidine-3-carboxylic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-4-{2-[Bis-(4-fluoro-phenyl)-pentafluorophenyl-methoxycarbonyl]-ethyl}-5-oxo-oxazolidine-3-carboxylic acid benzyl ester

There total 4 articles about (S)-4-{2-[Bis-(4-fluoro-phenyl)-pentafluorophenyl-methoxycarbonyl]-ethyl}-5-oxo-oxazolidine-3-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

(S)-3-[3-(benzyloxycarbonyl)-5-oxooxazolidin-4-yl]propanoic acid (23632-67-9) + 1-[Chloro-bis-(4-fluoro-phenyl)-methyl]-2,3,4,5,6-pentafluoro-benzene (241823-94-9) → (S)-4-{2-[Bis-(4-fluoro-phenyl)-pentafluorophenyl-methoxycarbonyl]-ethyl}-5-oxo-oxazolidine-3-carboxylic acid benzyl ester (241823-95-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 14h;

Reference yield:

bromopentafluorobenzene (344-04-7) → (S)-4-{2-[Bis-(4-fluoro-phenyl)-pentafluorophenyl-methoxycarbonyl]-ethyl}-5-oxo-oxazolidine-3-carboxylic acid benzyl ester (241823-95-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: Mg / diethyl ether

1.2: 94 percent / diethyl ether / 3 h / Heating

2.1: 100 percent / SOCl₂ / 0.17 h / 20 °C

3.1: 49 percent / DIPEA / CH₂Cl₂ / 14 h / 20 °C

With thionyl chloride; magnesium; N-ethyl-N,N-diisopropylamine; In diethyl ether; dichloromethane; 1.1: Metallation / 1.2: Grignard reaction / 2.1: Substitution / 3.1: Alkylation;

Reference yield:

4,4'-Difluorobenzophenone (345-92-6) → (S)-4-{2-[Bis-(4-fluoro-phenyl)-pentafluorophenyl-methoxycarbonyl]-ethyl}-5-oxo-oxazolidine-3-carboxylic acid benzyl ester (241823-95-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: Mg / diethyl ether

1.2: 94 percent / diethyl ether / 3 h / Heating

2.1: 100 percent / SOCl₂ / 0.17 h / 20 °C

3.1: 49 percent / DIPEA / CH₂Cl₂ / 14 h / 20 °C

With thionyl chloride; magnesium; N-ethyl-N,N-diisopropylamine; In diethyl ether; dichloromethane; 1.1: Metallation / 1.2: Grignard reaction / 2.1: Substitution / 3.1: Alkylation;

upstream raw materials:

(S)-3-[3-(benzyloxycarbonyl)-5-oxooxazolidin-4-yl]propanoic acid

1-[Chloro-bis-(4-fluoro-phenyl)-methyl]-2,3,4,5,6-pentafluoro-benzene

bromopentafluorobenzene

4,4'-Difluorobenzophenone

Downstream raw materials:

(S)-3-[3-(benzyloxycarbonyl)-5-oxooxazolidin-4-yl]propanoic acid