N-(2-(4-((3-(dimethylamino)propyl)amino)quinazolin-2-yl)phenyl)-3-morpholinopropanamide

Base Information

Chemical Name:N-(2-(4-((3-(dimethylamino)propyl)amino)quinazolin-2-yl)phenyl)-3-morpholinopropanamide
CAS No.:1443276-52-5
Molecular Formula:C₂₆H₃₄N₆O₂
Molecular Weight:462.595
Hs Code.:

Synonyms:N-(2-(4-((3-(dimethylamino)propyl)amino)quinazolin-2-yl)phenyl)-3-morpholinopropanamide

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Chemical Property of N-(2-(4-((3-(dimethylamino)propyl)amino)quinazolin-2-yl)phenyl)-3-morpholinopropanamide

Chemical Property:

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Technology Process of N-(2-(4-((3-(dimethylamino)propyl)amino)quinazolin-2-yl)phenyl)-3-morpholinopropanamide

There total 9 articles about N-(2-(4-((3-(dimethylamino)propyl)amino)quinazolin-2-yl)phenyl)-3-morpholinopropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 110-91-8,99108-56-2
morpholine

: 1443276-45-6
3-chloro-N-(2-(4-((3-(dimethylamino)propyl)amino)quinazolin-2-yl)phenyl)propanamide

: 1443276-52-5
N-(2-(4-((3-(dimethylamino)propyl)amino)quinazolin-2-yl)phenyl)-3-morpholinopropanamide

Guidance literature:: In methanol; ethanol; for 6h; Reflux;
DOI:10.1016/j.ejmech.2013.01.051

Reference yield:

: 610-14-0
2-nitrobenzyl chloride

: 1443276-52-5
N-(2-(4-((3-(dimethylamino)propyl)amino)quinazolin-2-yl)phenyl)-3-morpholinopropanamide

Guidance literature:: Multi-step reaction with 7 steps

1: triethylamine / chloroform / 5 h / 20 °C

2: potassium hydroxide / ethanol / 2 h / Reflux

3: N,N-diethylaniline; trichlorophosphate / toluene / 6 h / 80 °C

4: tetrahydrofuran / 5 h / Reflux

5: hydrogenchloride; tin(II) chloride dihdyrate / ethanol; water / 5 h / Reflux

6: dichloromethane / 0 - 20 °C

7: ethanol; methanol / 6 h / Reflux

With hydrogenchloride; tin(II) chloride dihdyrate; triethylamine; N,N-diethylaniline; potassium hydroxide; trichlorophosphate; In tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform; water; toluene;
DOI:10.1016/j.ejmech.2013.01.051

Reference yield:

: 36567-87-0
2-(2'-nitrophenyl)-4(3H)-quinazolinone

: 1443276-52-5
N-(2-(4-((3-(dimethylamino)propyl)amino)quinazolin-2-yl)phenyl)-3-morpholinopropanamide

Guidance literature:: Multi-step reaction with 5 steps

1: N,N-diethylaniline; trichlorophosphate / toluene / 6 h / 80 °C

2: tetrahydrofuran / 5 h / Reflux

3: hydrogenchloride; tin(II) chloride dihdyrate / ethanol; water / 5 h / Reflux

4: dichloromethane / 0 - 20 °C

5: ethanol; methanol / 6 h / Reflux

With hydrogenchloride; tin(II) chloride dihdyrate; N,N-diethylaniline; trichlorophosphate; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; toluene;
DOI:10.1016/j.ejmech.2013.01.051