(E)-tert-butyl 5-(2-methyl-5-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamido)styryl)pyrazin-2-ylcarbamate

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Chemical Name:(E)-tert-butyl 5-(2-methyl-5-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamido)styryl)pyrazin-2-ylcarbamate
CAS No.:1315380-92-7
Molecular Formula:C₃₂H₃₇F₃N₆O₃
Molecular Weight:610.679
Hs Code.:

Synonyms:(E)-tert-butyl 5-(2-methyl-5-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamido)styryl)pyrazin-2-ylcarbamate

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Chemical Property of (E)-tert-butyl 5-(2-methyl-5-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamido)styryl)pyrazin-2-ylcarbamate

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Technology Process of (E)-tert-butyl 5-(2-methyl-5-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamido)styryl)pyrazin-2-ylcarbamate

There total 6 articles about (E)-tert-butyl 5-(2-methyl-5-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamido)styryl)pyrazin-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1001419-29-9
tert-butyl 5-((diethoxyphosphoryl)methyl)pyrazin-2-ylcarbamate

: 1315380-91-6
N-(3-formyl-4-methylphenyl)-4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamide

: 1315380-92-7
(E)-tert-butyl 5-(2-methyl-5-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamido)styryl)pyrazin-2-ylcarbamate

Guidance literature:: tert-butyl 5-((diethoxyphosphoryl)methyl)pyrazin-2-ylcarbamate; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃;

N-(3-formyl-4-methylphenyl)-4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamide; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 7335-32-2
ethyl 5-amino-2-methylbenzoate

: 1315380-92-7
(E)-tert-butyl 5-(2-methyl-5-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamido)styryl)pyrazin-2-ylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / tetrahydrofuran / 5 h / 20 °C

2.1: potassium carbonate / acetonitrile / 8 h / 20 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 20 °C

4.1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 12 h / 20 °C / Molecular sieve

5.1: sodium hydride / N,N-dimethyl-formamide / 0 °C

5.2: 20 °C

With lithium aluminium tetrahydride; tetrapropylammonium perruthennate; sodium hydride; potassium carbonate; 4-methylmorpholine N-oxide; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1315380-89-2
ethyl 2-methyl-5-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamido)benzoate

: 1315380-92-7
(E)-tert-butyl 5-(2-methyl-5-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamido)styryl)pyrazin-2-ylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 20 °C

2.1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 12 h / 20 °C / Molecular sieve

3.1: sodium hydride / N,N-dimethyl-formamide / 0 °C

3.2: 20 °C

With lithium aluminium tetrahydride; tetrapropylammonium perruthennate; sodium hydride; 4-methylmorpholine N-oxide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;