(2R,4R)-2-[(4S,5R)-3-((1R)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethyl)-4-methyl-4,5-dihydroisoxazol-5-yl]-5-[(4-methoxybenzyl)oxy]-4-methylpentan-2-ol

Base Information

Chemical Name:(2R,4R)-2-[(4S,5R)-3-((1R)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethyl)-4-methyl-4,5-dihydroisoxazol-5-yl]-5-[(4-methoxybenzyl)oxy]-4-methylpentan-2-ol
CAS No.:863663-18-7
Molecular Formula:C₂₇H₄₇NO₅Si
Molecular Weight:493.759
Hs Code.:

Synonyms:(2R,4R)-2-[(4S,5R)-3-((1R)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethyl)-4-methyl-4,5-dihydroisoxazol-5-yl]-5-[(4-methoxybenzyl)oxy]-4-methylpentan-2-ol

Suppliers and Price of (2R,4R)-2-[(4S,5R)-3-((1R)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethyl)-4-methyl-4,5-dihydroisoxazol-5-yl]-5-[(4-methoxybenzyl)oxy]-4-methylpentan-2-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2R,4R)-2-[(4S,5R)-3-((1R)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethyl)-4-methyl-4,5-dihydroisoxazol-5-yl]-5-[(4-methoxybenzyl)oxy]-4-methylpentan-2-ol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,4R)-2-[(4S,5R)-3-((1R)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethyl)-4-methyl-4,5-dihydroisoxazol-5-yl]-5-[(4-methoxybenzyl)oxy]-4-methylpentan-2-ol

There total 5 articles about (2R,4R)-2-[(4S,5R)-3-((1R)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethyl)-4-methyl-4,5-dihydroisoxazol-5-yl]-5-[(4-methoxybenzyl)oxy]-4-methylpentan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: C₁₂H₁₇BrMgO₂

: 863663-16-5
(1R)-1-[(4S,5R)-3-((1R)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethyl)-4-methyl-4,5-dihydroisoxazol-5-yl]ethanone

: 863663-18-7
(2R,4R)-2-[(4S,5R)-3-((1R)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethyl)-4-methyl-4,5-dihydroisoxazol-5-yl]-5-[(4-methoxybenzyl)oxy]-4-methylpentan-2-ol

: (2S,4R)-2-[(4S,5R)-3-((1R)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethyl)-4-methyl-4,5-dihydroisoxazol-5-yl]-5-[(4-methoxybenzyl)oxy]-4-methylpentan-2-ol

Guidance literature:: With tert.-butyl lithium; magnesium bromide; In diethyl ether; various solvents; pentane; at -78 ℃; for 1h;
DOI:10.1002/anie.200500172

Reference yield: 64.0%

: 863663-16-5
(1R)-1-[(4S,5R)-3-((1R)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethyl)-4-methyl-4,5-dihydroisoxazol-5-yl]ethanone

: 143236-60-6
1-{[(2S)-3-bromo-2-methylpropyl]oxy}-4-methoxybenzene

: 863663-18-7
(2R,4R)-2-[(4S,5R)-3-((1R)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethyl)-4-methyl-4,5-dihydroisoxazol-5-yl]-5-[(4-methoxybenzyl)oxy]-4-methylpentan-2-ol

Guidance literature:: 1-{[(2S)-3-bromo-2-methylpropyl]oxy}-4-methoxybenzene; With tert.-butyl lithium; magnesium bromide; In diethyl ether; pentane; benzene; at -78 ℃; for 0.166667h;

(1R)-1-[(4S,5R)-3-((1R)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethyl)-4-methyl-4,5-dihydroisoxazol-5-yl]ethanone; In tetrahydrofuran; diethyl ether; pentane; benzene; at -78 ℃; for 1h;
DOI:10.1021/jo901817b

Reference yield:

: C₁₀H₂₂ClNO₂Si

: 863663-18-7
(2R,4R)-2-[(4S,5R)-3-((1R)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethyl)-4-methyl-4,5-dihydroisoxazol-5-yl]-5-[(4-methoxybenzyl)oxy]-4-methylpentan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 1.20 g / EtMgBr / CH₂Cl₂; diethyl ether; propan-2-ol / 0 - 20 °C

2: 82 percent / TPAP; NMO; 4 Angstroem molecular sieves / CH₂Cl₂ / 2 h / 20 °C

3: 64 percent / t-BuLi; MgBr₂ / diethyl ether; pentane; various solvents / 1 h / -78 °C

With N-methyl-2-indolinone; tetrapropylammonium perruthennate; 4 A molecular sieve; ethylmagnesium bromide; tert.-butyl lithium; magnesium bromide; In diethyl ether; dichloromethane; various solvents; isopropyl alcohol; pentane;
DOI:10.1002/anie.200500172