N-{4-[4-amino-6-(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)thieno[2,3-d]pyrimidin-5-yl]phenyl}-N'-(3-methylphenyl)urea

Base Information

Chemical Name:N-{4-[4-amino-6-(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)thieno[2,3-d]pyrimidin-5-yl]phenyl}-N'-(3-methylphenyl)urea
CAS No.:1055710-63-8
Molecular Formula:C₂₈H₃₅N₅O₂SSi
Molecular Weight:533.77
Hs Code.:

Synonyms:N-{4-[4-amino-6-(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)thieno[2,3-d]pyrimidin-5-yl]phenyl}-N'-(3-methylphenyl)urea

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Chemical Property of N-{4-[4-amino-6-(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)thieno[2,3-d]pyrimidin-5-yl]phenyl}-N'-(3-methylphenyl)urea

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Technology Process of N-{4-[4-amino-6-(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)thieno[2,3-d]pyrimidin-5-yl]phenyl}-N'-(3-methylphenyl)urea

There total 8 articles about N-{4-[4-amino-6-(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)thieno[2,3-d]pyrimidin-5-yl]phenyl}-N'-(3-methylphenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1055710-56-9
5-(4-aminophenyl)-6-(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)thieno[2,3-d]pyrimidin-4-amine

: 621-29-4
3-tolyl isocyanate

: 1055710-63-8
N-{4-[4-amino-6-(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)thieno[2,3-d]pyrimidin-5-yl]phenyl}-N'-(3-methylphenyl)urea

Guidance literature:: In dichloromethane; at 0 - 20 ℃;
DOI:10.1021/jm050458h

Reference yield:

: 605661-31-2
4-{[tert-butyl (dimethyl)silyl]oxy}-1-(4-nitrophenyl)butan-1-one

: 1055710-63-8
N-{4-[4-amino-6-(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)thieno[2,3-d]pyrimidin-5-yl]phenyl}-N'-(3-methylphenyl)urea

Guidance literature:: Multi-step reaction with 5 steps

1: NH₄OAc; AcOH / benzene / 18 h / Heating

2: Et₂NH; sulfur / ethanol / 1.5 h / 70 °C

3: 1.17 h / 180 °C / microwave irradiation

4: Fe; aq. NH₄Cl / ethanol; tetrahydrofuran / 2 h / 80 °C

5: CH₂Cl₂ / 0 - 20 °C

With ammonium acetate; iron; ammonium chloride; sulfur; acetic acid; diethylamine; In tetrahydrofuran; ethanol; dichloromethane; benzene; 1: Knoevenagel condensation / 2: Gewald reaction;
DOI:10.1021/jm050458h

Reference yield:

: 2-[4-(tert-butyl-dimethyl-silanyloxy)-1-(4-nitro-phenyl)-butylidene]-malononitrile

: 1055710-63-8
N-{4-[4-amino-6-(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)thieno[2,3-d]pyrimidin-5-yl]phenyl}-N'-(3-methylphenyl)urea

Guidance literature:: Multi-step reaction with 4 steps

1: Et₂NH; sulfur / ethanol / 1.5 h / 70 °C

2: 1.17 h / 180 °C / microwave irradiation

3: Fe; aq. NH₄Cl / ethanol; tetrahydrofuran / 2 h / 80 °C

4: CH₂Cl₂ / 0 - 20 °C

With iron; ammonium chloride; sulfur; diethylamine; In tetrahydrofuran; ethanol; dichloromethane; 1: Gewald reaction;
DOI:10.1021/jm050458h