605661-31-2Relevant academic research and scientific papers
Microwave-accelerated fluorodenitrations and nitrodehalogenations: expeditious routes to labeled PET ligands and fluoropharmaceuticals
LaBeaume, Paul,Placzek, Michael,Daniels, Mathew,Kendrick, Ian,Ng, Patrick,McNeel, Melissa,Afroze, Roushan,Alexander, Abigail,Thomas, Rhiannon,Kallmerten, Amy E.,Jones, Graham B.
scheme or table, p. 1906 - 1909 (2010/09/07)
Methods for the expeditious fluorination of arenes have been investigated, using readily available fluoride sources. An optimized procedure for microwave-accelerated fluorodenitration has been developed, giving good to excellent yields in less than 10 min, rendering it practical for use in the preparation of F18 labeled ligands for PET imaging. Application of the method in the synthesis of CNS agents is demonstrated, and a practical method for the preparation of substrates is also presented.
Thienopyrimidine ureas as novel and potent multitargeted receptor tyrosine kinase inhibitors
Dai, Yujia,Guo, Yan,Frey, Robin R.,Ji, Zhiqin,Curtin, Michael L.,Ahmed, Asma A.,Albert, Daniel H.,Arnold, Lee,Arries, Shannon S.,Barlozzari, Teresa,Bauch, Joy L.,Bouska, Jennifer J.,Bousquet, Peter F.,Cunha, George A.,Glaser, Keith B.,Guo, Jun,Li, Junling,Marcotte, Patrick A.,Marsh, Kennan C.,Moskey, Maria D.,Pease, Lori J.,Stewart, Kent D.,Stoll, Vincent S.,Tapang, Paul,Wishart, Neil,Davidsen, Steven K.,Michaelides, Michael R.
, p. 6066 - 6083 (2007/10/03)
A series of novel thienopyrimidine-based receptor tyrosine kinase inhibitors has been discovered. Investigation of structure-activity relationships at the 5- and 6-positions of the thienopyrimidine nucleus led to a series of N,N′-diaryl ureas that potentl
Thiopyrimidine and isothiazolopyrimidine kinase inhibitors
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Page/Page column 28, (2008/06/13)
Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
Thiopyrimidine and isothiazolopyrimidine kinase inhibitors
-
, (2008/06/13)
Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compound, compositions containing the compounds, and methods of treatment using the compounds.
Thiopyrimidine and isothiazolopyrimidine kinase inhibitors
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Page 28, (2010/02/05)
Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
