4,4'-dibenzyloxy-3-<(R,S)-2-(tert-butoxycarbonylamino)-2-methoxycarbonyl-1-oxoethyl>-3'-(1,3-dioxan-2-yl)biphenyl

Base Information

Chemical Name:4,4'-dibenzyloxy-3-<(R,S)-2-(tert-butoxycarbonylamino)-2-methoxycarbonyl-1-oxoethyl>-3'-(1,3-dioxan-2-yl)biphenyl
CAS No.:146335-30-0
Molecular Formula:C₃₉H₄₁NO₉
Molecular Weight:667.756
Hs Code.:

Synonyms:4,4'-dibenzyloxy-3-<(R,S)-2-(tert-butoxycarbonylamino)-2-methoxycarbonyl-1-oxoethyl>-3'-(1,3-dioxan-2-yl)biphenyl

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Chemical Property of 4,4'-dibenzyloxy-3-<(R,S)-2-(tert-butoxycarbonylamino)-2-methoxycarbonyl-1-oxoethyl>-3'-(1,3-dioxan-2-yl)biphenyl

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Technology Process of 4,4'-dibenzyloxy-3-<(R,S)-2-(tert-butoxycarbonylamino)-2-methoxycarbonyl-1-oxoethyl>-3'-(1,3-dioxan-2-yl)biphenyl

There total 9 articles about 4,4'-dibenzyloxy-3-<(R,S)-2-(tert-butoxycarbonylamino)-2-methoxycarbonyl-1-oxoethyl>-3'-(1,3-dioxan-2-yl)biphenyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 61172-71-2
2-(tert-butoxycarbonylamino)-3-methoxy-3-oxopropanoic acid

: 146335-29-7
4,4'-Bis-benzyloxy-3'-[1,3]dioxan-2-yl-biphenyl-3-carbonyl chloride

: 146335-30-0
4,4'-dibenzyloxy-3-<(R,S)-2-(tert-butoxycarbonylamino)-2-methoxycarbonyl-1-oxoethyl>-3'-(1,3-dioxan-2-yl)biphenyl

Guidance literature:: With n-butyllithium;
DOI:10.1055/s-1993-25933

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 146335-30-0
4,4'-dibenzyloxy-3-<(R,S)-2-(tert-butoxycarbonylamino)-2-methoxycarbonyl-1-oxoethyl>-3'-(1,3-dioxan-2-yl)biphenyl

Guidance literature:: Multi-step reaction with 3 steps

1: 81 percent / 1M aq. KHCO₃ / 24 h / Ambient temperature

2: 91 percent / 1M aq. NaOH / dioxane / 15 h / Ambient temperature

3: 1) n-BuLi / 1) THF, hexane, -70 deg C, 20 min, 2a) -70 deg C to RT, 2b) RT, 15 h

With sodium hydroxide; n-butyllithium; potassium hydrogencarbonate; In 1,4-dioxane;
DOI:10.1055/s-1992-26351

Reference yield:

: 61172-70-1
dimethyl 2-(tert-butoxycarbonylamino)malonate

: 146335-30-0
4,4'-dibenzyloxy-3-<(R,S)-2-(tert-butoxycarbonylamino)-2-methoxycarbonyl-1-oxoethyl>-3'-(1,3-dioxan-2-yl)biphenyl

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / 1M aq. NaOH / dioxane / 15 h / Ambient temperature

2: 1) n-BuLi / 1) THF, hexane, -70 deg C, 20 min, 2a) -70 deg C to RT, 2b) RT, 15 h

With sodium hydroxide; n-butyllithium; In 1,4-dioxane;
DOI:10.1055/s-1992-26351