61172-70-1

Usage

Uses

Used in Pharmaceutical Industry:
DIMETHYL (BOC-AMINO)MALONATE is used as a key intermediate for the synthesis of various pharmaceuticals and bioactive compounds. Its Boc-amino group facilitates the creation of complex molecular structures, contributing to the development of new drugs and therapeutic agents.
Used in Medicinal Chemistry and Drug Discovery:
DIMETHYL (BOC-AMINO)MALONATE is utilized as a building block in the preparation of peptides, which are essential in medicinal chemistry and drug discovery. Its unique properties allow for the design and synthesis of peptide-based drugs with potential therapeutic applications.
Used in Agrochemical Production:
In the agrochemical industry, DIMETHYL (BOC-AMINO)MALONATE is employed in the synthesis of various agrochemicals. Its versatility in organic synthesis enables the development of new compounds with potential applications in agriculture, such as pesticides and herbicides.
Used in Materials Science:
DIMETHYL (BOC-AMINO)MALONATE also finds applications in materials science, where it is used in the development of novel materials with specific properties. Its ability to form complex structures makes it a valuable component in the synthesis of advanced materials for various applications.
Overall, DIMETHYL (BOC-AMINO)MALONATE is a versatile chemical compound with significant applications across multiple industries, including pharmaceuticals, medicinal chemistry, agrochemicals, and materials science. Its unique properties and reactivity make it an essential building block in the synthesis of biologically active molecules and the development of innovative products.

InChI:InChI=1/C10H17NO6/c1-10(2,3)17-9(14)11-6(7(12)15-4)8(13)16-5/h6H,1-5H3,(H,11,14)

Upstream product

• 186581-53-3 diazomethane 
• 1070-19-5 N-(tert-butyloxycarbonyl) azide 
• 16115-80-3 dimethyl aminomalonate hydrochloride 
• 24424-99-5 di-tert-butyl dicarbonate 
• 53704-09-9 dimethyl 2-aminomalonate 
• 124-41-4 sodium methylate 
• 102831-44-7 diethyl tert-butoxycarbonylaminomalonate 

Downstream Products

• 612531-51-8 2-(3-benzyloxy-4-nitro-benzyl)-2-t-butoxycarbonylamino-malonic acid dimethyl ester 
• 143164-87-8 (2S,3R)-2-((2S,4R)-5-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-4-hydroxy-pentanoylamino)-3-{4,4'-bis-benzyloxy-3'-[(S)-2-benzyloxycarbonylamino-2-(2-trimethylsilanyl-ethoxycarbonyl)-ethyl]-biphenyl-3-yl}-3-hydroxy-propionic acid methyl ester 
• 143164-87-8 (2R,3S)-2-((2S,4R)-5-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-4-hydroxy-pentanoylamino)-3-{4,4'-bis-benzyloxy-3'-[(S)-2-benzyloxycarbonylamino-2-(2-trimethylsilanyl-ethoxycarbonyl)-ethyl]-biphenyl-3-yl}-3-hydroxy-propionic acid methyl ester 
• 146335-31-1 4,4'-dibenzyloxy-3-<(S)-2-(tert-butoxycarbonylamino)-2-methoxycarbonyl-(R)-1-hydroxyethyl>-3'-(1,3-dioxan-2-yl)biphenyl 
• 146335-31-1 4,4'-dibenzyloxy-3-<(R)-2-(tert-butoxycarbonylamino)-2-methoxycarbonyl-(R)-1-hydroxyethyl>-3'-(1,3-dioxan-2-yl)biphenyl 
• 146335-31-1 3-(4,4'-Bis-benzyloxy-3'-[1,3]dioxan-2-yl-biphenyl-3-yl)-2-tert-butoxycarbonylamino-3-hydroxy-propionic acid methyl ester 
• 143164-86-7 C₆₇H₈₀N₄O₁₅Si 
• 871206-25-6 (2S,3R)-2-((2S,4R)-2-Amino-5-benzyloxycarbonylamino-4-hydroxy-pentanoylamino)-3-[4,4'-bis-benzyloxy-3'-((S)-2-benzyloxycarbonylamino-2-pentafluorophenyloxycarbonyl-ethyl)-biphenyl-3-yl]-3-hydroxy-propionic acid methyl ester 
• 146388-30-9 (7R,8S,11S,14S)-5,17-Bis-benzyloxy-14-benzyloxycarbonylamino-11-((R)-3-benzyloxycarbonylamino-2-hydroxy-propyl)-7-hydroxy-10,13-dioxo-9,12-diaza-tricyclo[14.3.1.1^2,6]henicosa-1⁽¹⁹⁾,2⁽²¹⁾,3,5,16⁽²⁰⁾,17-hexaene-8-carboxylic acid methyl ester 
• 146335-30-0 4,4'-dibenzyloxy-3-<(R,S)-2-(tert-butoxycarbonylamino)-2-methoxycarbonyl-1-oxoethyl>-3'-(1,3-dioxan-2-yl)biphenyl 
• 146388-29-6 (2S,3R)-2-((2S,4R)-5-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-4-hydroxy-pentanoylamino)-3-[4,4'-bis-benzyloxy-3'-((S)-2-benzyloxycarbonylamino-2-pentafluorophenyloxycarbonyl-ethyl)-biphenyl-3-yl]-3-hydroxy-propionic acid methyl ester 
• 143164-84-5 3-<(S)-2-(benzyloxycarbonylamino)-2-(trimethylsilylethoxycarbonyl)ethyl>-3'-<(S)-2-(tert-butoxycarbonylamino)-2-(methoxycarbonyl)-(R)-1-hydroxyethyl>-4,4'-dibenzyloxybiphenyl 
• 143164-83-4 4,4'-dibenzyloxy-3-<(S)-2-(tert-butoxycarbonylamino)-2-(methoxycarbonyl)-(R)-1-hydroxyethyl>-3'-<(Z)-2-(benzyloxycarbonylamino)-2-(trimethylsilylethoxycarbonyl)vinyl>biphenyl 
• 1027532-24-6 (2S,3R)-2-Amino-3-{4,4'-bis-benzyloxy-3'-[(S)-2-benzyloxycarbonylamino-2-(2-trimethylsilanyl-ethoxycarbonyl)-ethyl]-biphenyl-3-yl}-3-hydroxy-propionic acid methyl ester 

Relevant academic research and scientific papers

Discovery of novel oxazole-based macrocycles as anti-coronaviral agents targeting SARS-CoV-2 main protease

We have discovered a family of synthetic oxazole-based macrocycles to be active against SARS-CoV-2. The synthesis, pharmacological properties, and docking studies of the compounds are reported in this study. The structure of the new macrocycles was confir

Barbituric acid derivatives as inhibitors of TNF-alpha converting enzyme (TACE) and/or matrix metalloproteinases

The present application describes novel barbituric acid derivatives of formula I: or pharmaceutically acceptable salt or prodrug forms thereof, wherein A, B, L, R1, R2, R3, R4, R5, n, W, U, X, Y, Z, U

Synthesis of a second-generation pseudopeptide platform

A synthetic pathway is presented to a functionalized pseudopeptide molecular platform for use in supramolecular and solution-phase combinatorial chemistry. The platform contains amino acids with quaternary asymmetric centers, the configurations of which are determined by the method of synthesis. (C) 2000 Elsevier Science Ltd.

Synthesis and reduction of endothiodipeptides containing malonic acid derivatives

Amides of malonic acid derivatives and protected dipeptides containing amine malonic acid have been synthesized and converted into the corresponding monothio analoga and endothiedipeptides. By reduction of the thioamides terminal protected β-carboxy amine derivatives were obtained. Reduction of endothiodipeptides containing amine malonic acid as the carboxy component resulted in protected Ψ[CH2NH] pseudodipeptides for the use as dipeptide substitutes with proteolytic resistance.

Dimethyl Aminomalonate: A Useful C-3 Unit in a Mild, Direct Synthesis of Oxazole-4-carboxylates

N-Acyl derivatives of the title compound undergo oxidative cyclization upon treatment with N-chlorosuccinimide in DMF to form dimethyl 4,5-dihydro-5-(phenylthio)oxazole-4,4-dicarboxylates 4 which then are decarbomethoxylated with concomitant loss of thiop

Total synthesis of the biphenomycins; V. Synthesis of biphenomycin A

The total synthesis of biphenomycin A is described. Two of the five stereogenic centres were formed by enantioselective hydrogenation of the corresponding didehydroamino acids using the rhodium-DIPAMP catalyst and the two stereogenic centres of the α-amin