(+)-(2S,3S)-5-<2-(N-benzyl-N-methylamino)ethyl>-2-(4-benzyloxyphenyl)-8-chloro-2,3-dihydro-3-hydroxy-2-(4-hydroxyphenyl)-1,5-benzothioazepin-4(5H)-one

Base Information

Chemical Name:(+)-(2S,3S)-5-<2-(N-benzyl-N-methylamino)ethyl>-2-(4-benzyloxyphenyl)-8-chloro-2,3-dihydro-3-hydroxy-2-(4-hydroxyphenyl)-1,5-benzothioazepin-4(5H)-one
CAS No.:112525-30-1
Molecular Formula:C₃₂H₃₁ClN₂O₃S
Molecular Weight:559.129
Hs Code.:

Synonyms:(+)-(2S,3S)-5-<2-(N-benzyl-N-methylamino)ethyl>-2-(4-benzyloxyphenyl)-8-chloro-2,3-dihydro-3-hydroxy-2-(4-hydroxyphenyl)-1,5-benzothioazepin-4(5H)-one

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Chemical Property of (+)-(2S,3S)-5-<2-(N-benzyl-N-methylamino)ethyl>-2-(4-benzyloxyphenyl)-8-chloro-2,3-dihydro-3-hydroxy-2-(4-hydroxyphenyl)-1,5-benzothioazepin-4(5H)-one

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Technology Process of (+)-(2S,3S)-5-<2-(N-benzyl-N-methylamino)ethyl>-2-(4-benzyloxyphenyl)-8-chloro-2,3-dihydro-3-hydroxy-2-(4-hydroxyphenyl)-1,5-benzothioazepin-4(5H)-one

There total 4 articles about (+)-(2S,3S)-5-<2-(N-benzyl-N-methylamino)ethyl>-2-(4-benzyloxyphenyl)-8-chloro-2,3-dihydro-3-hydroxy-2-(4-hydroxyphenyl)-1,5-benzothioazepin-4(5H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 23510-18-1
2-(N-benzyl-N-methylamino)ethyl chloride hydrochloride

: 112525-28-7
(+)-(2S,3S)-2-(4-benzyloxyphenyl)-8-chloro-2,3-dihydro-3-hydroxy-2-(4-hydroxyphenyl)-1,5-benzothioazepin-4(5H)-one

: 112525-30-1
(+)-(2S,3S)-5-<2-(N-benzyl-N-methylamino)ethyl>-2-(4-benzyloxyphenyl)-8-chloro-2,3-dihydro-3-hydroxy-2-(4-hydroxyphenyl)-1,5-benzothioazepin-4(5H)-one

Guidance literature:: With potassium carbonate; In acetone; for 20h; Heating;
DOI:10.1248/cpb.42.167

Reference yield:

: 100-39-0
benzyl bromide

: 112525-30-1
(+)-(2S,3S)-5-<2-(N-benzyl-N-methylamino)ethyl>-2-(4-benzyloxyphenyl)-8-chloro-2,3-dihydro-3-hydroxy-2-(4-hydroxyphenyl)-1,5-benzothioazepin-4(5H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: 54 percent / K₂CO₃ / methanol; H₂O / 1 h / 70 °C

2: 100 percent / K₂CO₃ / acetone / 20 h / Heating

With potassium carbonate; In methanol; water; acetone;
DOI:10.1248/cpb.42.167

Reference yield:

: 96142-63-1
(+)-(2S,3S)-8-chloro-3-hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-5H-1,5-benzothiazepin-4-one

: 112525-30-1
(+)-(2S,3S)-5-<2-(N-benzyl-N-methylamino)ethyl>-2-(4-benzyloxyphenyl)-8-chloro-2,3-dihydro-3-hydroxy-2-(4-hydroxyphenyl)-1,5-benzothioazepin-4(5H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: 98.2 percent / NaI, TMSCl / acetonitrile / 17 h / 60 °C

2: 54 percent / K₂CO₃ / methanol; H₂O / 1 h / 70 °C

3: 100 percent / K₂CO₃ / acetone / 20 h / Heating

With chloro-trimethyl-silane; potassium carbonate; sodium iodide; In methanol; water; acetone; acetonitrile;
DOI:10.1248/cpb.42.167