1-[(4aR,6R,8aS)-3,4,4a,5,6,7,8,8a-octahydro-8a-methyl-6-(phenylmethoxy)naphthalen-1-yl]ethanone

Base Information

Chemical Name:1-[(4aR,6R,8aS)-3,4,4a,5,6,7,8,8a-octahydro-8a-methyl-6-(phenylmethoxy)naphthalen-1-yl]ethanone
CAS No.:652153-20-3
Molecular Formula:C₂₀H₂₆O₂
Molecular Weight:298.425
Hs Code.:

Synonyms:1-[(4aR,6R,8aS)-3,4,4a,5,6,7,8,8a-octahydro-8a-methyl-6-(phenylmethoxy)naphthalen-1-yl]ethanone

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Chemical Property of 1-[(4aR,6R,8aS)-3,4,4a,5,6,7,8,8a-octahydro-8a-methyl-6-(phenylmethoxy)naphthalen-1-yl]ethanone

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Technology Process of 1-[(4aR,6R,8aS)-3,4,4a,5,6,7,8,8a-octahydro-8a-methyl-6-(phenylmethoxy)naphthalen-1-yl]ethanone

There total 4 articles about 1-[(4aR,6R,8aS)-3,4,4a,5,6,7,8,8a-octahydro-8a-methyl-6-(phenylmethoxy)naphthalen-1-yl]ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 81927-55-1
O-benzyl 2,2,2-trichloroacetimidate

: 652153-19-0
1-[(4aR,6R,8aS)-3,4,4a,5,6,7,8,8a-octahydro-6-hydroxy-8a-methylnaphthalen-1-yl]ethanone

: 652153-20-3
1-[(4aR,6R,8aS)-3,4,4a,5,6,7,8,8a-octahydro-8a-methyl-6-(phenylmethoxy)naphthalen-1-yl]ethanone

Guidance literature:: With trifluorormethanesulfonic acid; In dichloromethane; at 0 ℃; for 1h;
DOI:10.1002/hlca.200390315

Reference yield:

: 652153-25-8
(4aR,6R,8aR)-6-hydroxy-8a-methyloctahydronaphthalen-1(2H)-one

: 652153-20-3
1-[(4aR,6R,8aS)-3,4,4a,5,6,7,8,8a-octahydro-8a-methyl-6-(phenylmethoxy)naphthalen-1-yl]ethanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium; NH₃ / -70 °C

1.2: 83 mg / diethyl ether

2.1: formic acid; H₂SO₄

2.2: 47 percent / K₂CO₃ / methanol; H₂O / 1 h

3.1: 77 percent / trifluoromethanesulfonic acid / CH₂Cl₂ / 1 h / 0 °C

With formic acid; trifluorormethanesulfonic acid; sulfuric acid; ammonia; sodium; In dichloromethane;
DOI:10.1002/hlca.200390315

Reference yield:

: C₁₃H₂₂O₃

: 652153-20-3
1-[(4aR,6R,8aS)-3,4,4a,5,6,7,8,8a-octahydro-8a-methyl-6-(phenylmethoxy)naphthalen-1-yl]ethanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: 88 percent / aq. H₂SO₄ / diethyl ether / 0.5 h

2.1: sodium; NH₃ / -70 °C

2.2: 83 mg / diethyl ether

3.1: formic acid; H₂SO₄

3.2: 47 percent / K₂CO₃ / methanol; H₂O / 1 h

4.1: 77 percent / trifluoromethanesulfonic acid / CH₂Cl₂ / 1 h / 0 °C

With formic acid; trifluorormethanesulfonic acid; sulfuric acid; ammonia; sodium; In diethyl ether; dichloromethane;
DOI:10.1002/hlca.200390315