6-chloro-2-ethyl-N-(4-(4-(4-fluorobenzoyl)piperazin-1-yl)benzyl)imidazo[1,2-a]pyridine-3-carboxamide

Base Information

• Chemical Name: 6-chloro-2-ethyl-N-(4-(4-(4-fluorobenzoyl)piperazin-1-yl)benzyl)imidazo[1,2-a]pyridine-3-carboxamide
• CAS No.: 1403940-97-5
• Molecular Formula: C₂₈H₂₇ClFN₅O₂
• Molecular Weight: 520.006
• Mol file: 1403940-97-5.mol

Synonyms:6-chloro-2-ethyl-N-(4-(4-(4-fluorobenzoyl)piperazin-1-yl)benzyl)imidazo[1,2-a]pyridine-3-carboxamide

Chemical Property of 6-chloro-2-ethyl-N-(4-(4-(4-fluorobenzoyl)piperazin-1-yl)benzyl)imidazo[1,2-a]pyridine-3-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-chloro-2-ethyl-N-(4-(4-(4-fluorobenzoyl)piperazin-1-yl)benzyl)imidazo[1,2-a]pyridine-3-carboxamide

There total 6 articles about 6-chloro-2-ethyl-N-(4-(4-(4-fluorobenzoyl)piperazin-1-yl)benzyl)imidazo[1,2-a]pyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

C21H24ClN5O*C2HF3O2 + 4-fluorobenzoyl chloride (403-43-0) → 6-chloro-2-ethyl-N-(4-(4-(4-fluorobenzoyl)piperazin-1-yl)benzyl)imidazo[1,2-a]pyridine-3-carboxamide (1403940-97-5)

Guidance literature:

C₂₁H₂₄ClN₅O*C₂HF₃O₂; 4-fluorobenzoyl chloride; With triethylamine; In dichloromethane; at 20 ℃; for 1.5h;

With trifluoroacetic acid;

Reference yield:

C21H24ClN5O + 4-fluorobenzoyl chloride (403-43-0) → 6-chloro-2-ethyl-N-(4-(4-(4-fluorobenzoyl)piperazin-1-yl)benzyl)imidazo[1,2-a]pyridine-3-carboxamide (1403940-97-5)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

DOI:10.1016/j.ejmech.2016.09.082

Reference yield:

C26H32ClN5O3 → 6-chloro-2-ethyl-N-(4-(4-(4-fluorobenzoyl)piperazin-1-yl)benzyl)imidazo[1,2-a]pyridine-3-carboxamide (1403940-97-5)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 16 h / 20 °C

2: triethylamine / dichloromethane / 1.5 h / 20 °C

With triethylamine; In tetrahydrofuran; dichloromethane;

upstream raw materials:

4-fluorobenzonitrile

tert-butyl 4-(4-cyanophenyl)piperazine-1-carboxylate

tert-butyl 4-[4-(aminomethyl)phenyl]piperazine-1-carboxylate

4-fluorobenzoyl chloride