METHYL 1-AMINOMETHYL-CYCLOHEXANECARBOXYLATE

Base Information

• Chemical Name: METHYL 1-AMINOMETHYL-CYCLOHEXANECARBOXYLATE
• CAS No.: 99092-04-3
• Molecular Formula: C9H17 N O2
• Molecular Weight: 171.239
• Hs Code.: 2922499990
• Mol file: 99092-04-3.mol

Synonyms:METHYL 1-AMINOMETHYL-CYCLOHEXANECARBOXYLATE;

Chemical Property of METHYL 1-AMINOMETHYL-CYCLOHEXANECARBOXYLATE

Chemical Property:

• Boiling Point: 235.2°Cat760mmHg
• Flash Point: 101.4°C
• PSA: 52.32000
• Density: 1.023g/cm³
• LogP: 1.76890
• Storage Temp.: 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

Methyl1-(aminomethyl)cyclohexanecarboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL 1-AMINOMETHYL-CYCLOHEXANECARBOXYLATE

There total 4 articles about METHYL 1-AMINOMETHYL-CYCLOHEXANECARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 1-cyanocyclohexane-1-carboxylate (58920-80-2) → methyl 1-(aminomethyl)cyclohexanecarboxylate (99092-04-3)

Guidance literature:

With hydrogen; nickel; In methanol; at 40 ℃; for 22h; under 3000.24 Torr; Yield given;

DOI:10.1002/(SICI)1522-2675(19981216)81:12<2218::AID-HLCA2218>3.0.CO;2-0

Reference yield:

1,5-dibromo-pentane (111-24-0) → methyl 1-(aminomethyl)cyclohexanecarboxylate (99092-04-3)

Guidance literature:

Multi-step reaction with 2 steps

1: NaH / tetrahydrofuran

2: PtO₂; H₂; aq. HCl / methanol

With hydrogenchloride; platinum(IV) oxide; hydrogen; sodium hydride; In tetrahydrofuran; methanol;

DOI:10.1016/j.bmcl.2006.02.015

Reference yield:

1-methoxy-1-trimethylsilyloxymethylenecyclohexane (40195-26-4) → methyl 1-(aminomethyl)cyclohexanecarboxylate (99092-04-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / Me₃SiOSO₂CF₃ / CH₂Cl₂ / Ambient temperature

2: MeOH / Heating

With methanol; trimethylsilyl trifluoromethanesulfonate; In dichloromethane;

DOI:10.1039/c39840000883

upstream raw materials:

methyl 1-cyanocyclohexane-1-carboxylate

1,5-dibromo-pentane

1-methoxy-1-trimethylsilyloxymethylenecyclohexane

methyl 1-(<<(tert-butoxy)carbonyl>amino>methyl)cyclohexane-1-carboxylate

Downstream raw materials:

methyl 1-(<<(tert-butoxy)carbonyl>amino>methyl)cyclohexane-1-carboxylate

C₂₀H₃₇N₃O₄

C₂₃H₃₅N₃O₄

C₁₁H₁₉NO₃

Refernces

• 1、 Basuroy, Krishnayan,Karuppiah, Vasantham,Shamala, Narayanaswamy,Balaram, Padmanabhan. "The structural characterization of folded peptides containing the conformationally constrained β-amino acid residue β 2,2Ac6c". . p. 2589 - 2603. Retrieved 2013/03/13.
• 2、 Gilmore, John L.,King, Bryan W.,Harris, Cathy,Maduskuie, Thomas,Mercer, Stephen E.,Liu, Rui-Qin,Covington, Maryanne B.,Qian, Mingxin,Ribadeneria, Maria D.,Vaddi, Krishna,Trzaskos, James M.,Newton, Robert C.,Decicco, Carl P.,Duan, James J.-W.. "Synthesis and structure-activity relationship of a novel, achiral series of TNF-α converting enzyme inhibitors". . p. 2699 - 2704. Retrieved 2007/10/03.