6-(4-methylphenyl)-N-[3-(1-pyrrolidinylmethyl)-7-quinolinyl]nicotinamide

Base Information

Chemical Name:6-(4-methylphenyl)-N-[3-(1-pyrrolidinylmethyl)-7-quinolinyl]nicotinamide
CAS No.:521070-57-5
Molecular Formula:C₂₇H₂₆N₄O
Molecular Weight:422.53
Hs Code.:

Synonyms:6-(4-methylphenyl)-N-[3-(1-pyrrolidinylmethyl)-7-quinolinyl]nicotinamide

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Chemical Property of 6-(4-methylphenyl)-N-[3-(1-pyrrolidinylmethyl)-7-quinolinyl]nicotinamide

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Technology Process of 6-(4-methylphenyl)-N-[3-(1-pyrrolidinylmethyl)-7-quinolinyl]nicotinamide

There total 6 articles about 6-(4-methylphenyl)-N-[3-(1-pyrrolidinylmethyl)-7-quinolinyl]nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 521073-96-1
3-(1-pyrrolidinylmethyl)-7-quinolinylamine hydrochloride

: 521074-77-1
6-(4-methylphenyl)nicotinic acid

: 521070-57-5
6-(4-methylphenyl)-N-[3-(1-pyrrolidinylmethyl)-7-quinolinyl]nicotinamide

Guidance literature:: With dmap; ethylene dichloride hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 16h; Cooling with ice;
DOI:10.1021/jm201596h

Reference yield:

: 521073-92-7
N-[3-(hydroxymethyl)-7-quinolinyl]acetamide

: 521070-57-5
6-(4-methylphenyl)-N-[3-(1-pyrrolidinylmethyl)-7-quinolinyl]nicotinamide

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride / 2 h / 20 °C

2: potassium carbonate / acetonitrile / 2 h / 80 °C

3: hydrogenchloride / 1 h / 100 °C

4: dmap; ethylene dichloride hydrochloride; triethylamine / N,N-dimethyl-formamide / 16 h / 20 °C / Cooling with ice

With hydrogenchloride; dmap; thionyl chloride; ethylene dichloride hydrochloride; potassium carbonate; triethylamine; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm201596h

Reference yield:

: 521073-93-8
N-[3-(chloromethyl)-7-quinolinyl]acetamide hydrochloride

: 521070-57-5
6-(4-methylphenyl)-N-[3-(1-pyrrolidinylmethyl)-7-quinolinyl]nicotinamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetonitrile / 2 h / 80 °C

2: hydrogenchloride / 1 h / 100 °C

3: dmap; ethylene dichloride hydrochloride; triethylamine / N,N-dimethyl-formamide / 16 h / 20 °C / Cooling with ice

With hydrogenchloride; dmap; ethylene dichloride hydrochloride; potassium carbonate; triethylamine; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm201596h