4-N-(N-cyclopropylthionocarbamoylmethyl)amino-5-phenyl-7-(5-deoxy-2,3-O-isopropylidenyl-β-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine

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Chemical Name:4-N-(N-cyclopropylthionocarbamoylmethyl)amino-5-phenyl-7-(5-deoxy-2,3-O-isopropylidenyl-β-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine
CAS No.:871672-05-8
Molecular Formula:C₂₅H₂₉N₅O₃S
Molecular Weight:479.603
Hs Code.:

Synonyms:4-N-(N-cyclopropylthionocarbamoylmethyl)amino-5-phenyl-7-(5-deoxy-2,3-O-isopropylidenyl-β-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine

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Chemical Property of 4-N-(N-cyclopropylthionocarbamoylmethyl)amino-5-phenyl-7-(5-deoxy-2,3-O-isopropylidenyl-β-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine

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Technology Process of 4-N-(N-cyclopropylthionocarbamoylmethyl)amino-5-phenyl-7-(5-deoxy-2,3-O-isopropylidenyl-β-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine

There total 10 articles about 4-N-(N-cyclopropylthionocarbamoylmethyl)amino-5-phenyl-7-(5-deoxy-2,3-O-isopropylidenyl-β-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 871671-59-9
4-N-(N-cyclopropylcarbamoylmethyl)amino-5-phenyl-7-(5-deoxy-2,3-O-isopropylidenyl-β-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine

: 871672-05-8
4-N-(N-cyclopropylthionocarbamoylmethyl)amino-5-phenyl-7-(5-deoxy-2,3-O-isopropylidenyl-β-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine

Guidance literature:: With Lawessons reagent; In tetrahydrofuran; at 20 ℃; for 96h;
DOI:10.1021/jm050394a

Reference yield:

: 120436-01-3
N-carbobenzyloxyglycine cyclopropylamide

: 871672-05-8
4-N-(N-cyclopropylthionocarbamoylmethyl)amino-5-phenyl-7-(5-deoxy-2,3-O-isopropylidenyl-β-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / H₂ / Pd/C / methanol / 16 h / 1551.44 Torr

2: 64 percent / butan-1-ol / 30 h / Heating

3: 53 percent / Lawesson reagent / tetrahydrofuran / 96 h / 20 °C

With Lawessons reagent; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; butan-1-ol;
DOI:10.1021/jm050394a

Reference yield:

: 120436-02-4
2-amino-N-cyclopropylacetamide

: 871672-05-8
4-N-(N-cyclopropylthionocarbamoylmethyl)amino-5-phenyl-7-(5-deoxy-2,3-O-isopropylidenyl-β-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: 64 percent / butan-1-ol / 30 h / Heating

2: 53 percent / Lawesson reagent / tetrahydrofuran / 96 h / 20 °C

With Lawessons reagent; In tetrahydrofuran; butan-1-ol;
DOI:10.1021/jm050394a